Evidence map›Paper›PMID 19684604›Full record

ArticleNature genetics2009

Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.

Elli Papaemmanuil, Fay J Hosking, Jayaram Vijayakrishnan, Amy Price, Bianca Olver, Eammon Sheridan, Sally E Kinsey, Tracy Lightfoot, Eve Roman, Julie A E Irving and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 248 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
248citing papers in PubMed, 15 pooled it
42.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

248 citing papers in PubMed, 15 syntheses or guidelines pooled it, 480 citations in OpenAlex.

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  12. ARID5B gene rs10821936 polymorphism is associated with childhood acute lymphoblastic leukemia: a meta-analysis based on 39,116 subjects.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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188 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Elli PapaemmanuilSection of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
Fay J Hosking
Jayaram Vijayakrishnan
Amy Price
Bianca Olver
Eammon Sheridan
Sally E Kinsey
Tracy Lightfoot
Eve Roman
Julie A E Irving
James M Allan
Ian P Tomlinson
Malcolm Taylor
Mel Greaves
Richard S Houlston
Institute of Cancer Research · GBNewcastle University · GBSt James's University Hospital · GBUniversity of York · GBCentre for Human Genetics · GBSt Mary's Hospital · GB

Funding

Cancer Research UK C1298/A8362Medical Research Council G0000934Wellcome Trust
6 · The paper itself

Abstract

To identify risk variants for childhood acute lymphoblastic leukemia (ALL), we conducted a genome-wide association study of two case-control series, analyzing the genotypes with respect to 291,423 tagging SNPs in a total of 907 ALL cases and 2,398 controls. We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 x 10(-19)) and 14q11.2 (CEBPE, rs2239633, OR = 1.34, P = 2.88 x 10(-7)). The 10q21.2 (ARID5B) risk association appears to be selective for the subset of B-cell precursor ALL with hyperdiploidy. These data show that common low-penetrance susceptibility alleles contribute to the risk of developing childhood ALL and provide new insight into disease causation of this specific hematological cancer. Notably, all three risk variants map to genes involved in transcriptional regulation and differentiation of B-cell progenitors.

Indexed as

Chromosomes, Human, Pair 10Chromosomes, Human, Pair 14Chromosomes, Human, Pair 7Genetic Predisposition to DiseaseAllelesBase PairingBase SequenceCase-Control StudiesCCAAT-Enhancer-Binding ProteinsChildChild, PreschoolConfidence IntervalsDNA-Binding ProteinsGene FrequencyGenetic VariationGenome-Wide Association StudyARID5B protein, humanCCAAT-Enhancer-Binding ProteinsCEBPE protein, humanDNA-Binding ProteinsIkaros Transcription FactorIKZF1 protein, humanTranscription Factors

Identifiers

PMID19684604
PMCPMC4915548
OpenAlexW1998823290

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.