ArticleBiology of reproduction2010
Accelerated ovarian aging in the absence of the transcription regulator TAF4B in mice.
Article in Biology of reproduction, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Coordinating meiotic prophase I progression and early oocyte differentiation.Development (Cambridge, England) · 2026Article
- Estropausal gut microbiota transplant improves measures of ovarian function in adult mice.Nature aging · 2026Article
- Mechanisms of Phthalate-Induced Accelerated Ovarian Aging in Experimental Models.Current environmental health reports · 2026Review
- N-acetylcysteine mitigates oxidative damage to the ovary in D-galactose-induced ovarian failure in rabbits.Molecular biology reports · 2024Article
- TAF4b transcription networks regulating early oocyte differentiation.Development (Cambridge, England) · 2022Article
- Modulation of Cathepsin S (Animals : an open access journal from MDPI · 2021Article
- ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis.Molecular and cellular biology · 2020Article
- Mechanisms controlling germline cyst breakdown and primordial follicle formation.Cellular and molecular life sciences : CMLS · 2017Review
- Multidrug resistance transporter-1 and breast cancer resistance protein protect against ovarian toxicity, and are essential in ovarian physiology.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis.PLoS genetics · 2016Article
- The double-edged sword of the mammalian oocyte--advantages, drawbacks and approaches for basic and clinical analysis at the single cell level.Molecular human reproduction · 2016Review
- The developmental origins of the mammalian ovarian reserve.Development (Cambridge, England) · 2015Review
- TAF4b is required for mouse spermatogonial stem cell development.Stem cells (Dayton, Ohio) · 2015Article
- Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis.BioMed research international · 2015Article
- TAF4b promotes mouse primordial follicle assembly and oocyte survival.Developmental biology · 2014Article
- Targeting TBP-Associated Factors in Ovarian Cancer.Frontiers in oncology · 2014Review
- Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors.Biology of reproduction · 2013Article
- Processing the complexities of transcription.Developmental cell · 2013Article
- Genetic markers of ovarian follicle number and menopause in women of multiple ethnicities.Human genetics · 2012Article
- Transcriptome variance in single oocytes within, and between, genotypes.Molecular reproduction and development · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian ovary is unique in that its reproductive life span is limited by oocyte quantity and quality. Oocytes are recruited from a finite pool of primordial follicles that are usually exhausted from the ovary during midadult life. If regulation of this pool is perturbed, the reproductive capacity of the ovary is compromised. TAF4B is a gonad-enriched subunit of the TFIID complex required for female fertility in mice. Previous characterization of TAF4B-deficient ovaries revealed several reproductive deficits that collectively result in infertility. However, the etiology of such fertility defects remains unknown. By assaying estrous cycle, ovarian pathology, and gene expression changes in young Taf4b-null female mice, we show that TAF4B-deficient female mice exhibit premature reproductive senescence. The rapid decline of ovarian function in Taf4b-null mice begins in early postnatal life, and follicle depletion is completed by 16 wk of age. To uncover differences in gene expression that may underlie accelerated ovarian aging, we compared genome-wide expression profiles of 3-wk-old, prepubescent Taf4b-null and wild-type ovaries. At 3 wk of age, decreased gene expression in Taf4b-null ovaries is similar to that seen in aged ovaries, revealing several molecular signatures of premature reproductive senescence, including reduced Smc1b. One significantly reduced transcript in the young TAF4B-null ovary codes for MOV10L1, a putative germline-specific RNA helicase that is related to the Drosophila RNA interference protein, armitage. We show here that Mov10l1 is expressed in mouse oocytes and that its expression is sensitive to TAF4B level, linking TAF4B to the posttranscriptional control of ovarian gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.