SynthesisBMJ (Clinical research ed.)2009
Excluding venous thromboembolism using point of care D-dimer tests in outpatients: a diagnostic meta-analysis.
Synthesis in BMJ (Clinical research ed.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 11 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Design-related bias in studies investigating diagnostic tests for venous thromboembolic diseases: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Developing more generalizable prediction models from pooled studies and large clustered data sets.Statistics in medicine · 2021Pooled it
- Comprehensive Outpatient Management of Low-Risk Pulmonary Embolism: Can Primary Care Do This? A Narrative Review.The Permanente journal · 2020Pooled it
- Accuracy of using serum D-dimer for diagnosis of acute intestinal ischemia: A meta-analysis.Medicine · 2017Pooled it
- Diagnostic prediction models for suspected pulmonary embolism: systematic review and independent external validation in primary care.BMJ (Clinical research ed.) · 2015Pooled it
- Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis.BMJ (Clinical research ed.) · 2014Pooled it
- FDG-PET in diagnosis, staging and prognosis of pancreatic carcinoma: a meta-analysis.World journal of gastroenterology · 2013Pooled it
- Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2013Pooled it
- Guideline
- Imaging in assessing hepatic and peritoneal metastases of gastric cancer: a systematic review.BMC gastroenterology · 2011Pooled it
- Meta-analysis: identification of low birthweight by other anthropometric measurements at birth in developing countries.Journal of epidemiology · 2011Pooled it
- Safety of a strategy combining D-dimer testing and whole-leg ultrasonography to rule out deep vein thrombosis.Blood advances · 2020Trial
- Evaluation of the Alere D-dimer test for point of care testing.Journal of thrombosis and thrombolysis · 2014Trial
- Reassessment strategy to reduce chest imaging in patients with suspected pulmonary embolism and elevated D-dimer: an exploratory cohort study.Research and practice in thrombosis and haemostasis · 2026Observational
- Short- and long-term risk stratification in acutely ill medical patients by implementing D-dimer in the emergency setting - A prospective cohort study.American heart journal plus : cardiology research and practice · 2026Article
- Acceptability of Cardiovascular Disease Point-of-Care Diagnostics in Primary Care Settings: A Scoping Review.Health science reports · 2026Review
- Advances in D-dimer testing: progress in harmonization of clinical assays and innovative detection methods.Analytical and bioanalytical chemistry · 2024Review
- How do we identify acute medical admissions that are suitable for same day emergency care?Clinical medicine (London, England) · 2022Review
- Relevant Biomarkers in Medical Practices: An Analysis of the Needs Addressed by an International Survey.Journal of personalized medicine · 2022Article
- Venous thromboembolism management and the new NICE guidance: what the busy GP needs to know.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review the evidence on the diagnostic accuracy of the currently available point of care D-dimer tests for excluding venous thromboembolism.
designSystematic review of research on the accuracy of point of care D-dimer tests, using bivariate regression to examine sources of variation and to estimate sensitivity and specificity. DATA SOURCES: Studies on the diagnostic accuracy of point of care D-dimer tests published between January 1995 and September 2008 and available in either Medline or Embase. Review methods The analysis included studies that compared point of care D-dimer tests with predefined reference criteria for venous thromboembolism, enrolled consecutive outpatients, and allowed for construction of a 2x2 table.
results23 studies (total number of patients 13 959, range in mean age 38-65 years, range of venous thromboembolism prevalence 4-51%) were included in the meta-analysis. The studies reported two qualitative point of care D-dimer tests (SimpliRED D-dimer (n=12) and Clearview Simplify D-dimer (n=7)) and two quantitative point of care D-dimer tests (Cardiac D-dimer (n=4) and Triage D-dimer (n=2)). Overall sensitivity ranged from 0.85 (95% confidence interval 0.78 to 0.90) to 0.96 (0.91 to 0.98) and overall specificity from 0.48 (0.33 to 0.62) to 0.74 (0.69 to 0.78). The two quantitative tests Cardiac D-dimer and Triage D-dimer scored most favourably.
conclusionsIn outpatients suspected of venous thromboembolism, point of care D-dimer tests can contribute important information and guide patient management, notably in low risk patients (that is, those patients with a low score on a clinical decision rule).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.