ArticleEuropean journal of histochemistry : EJH
Nuclei of aged myofibres undergo structural and functional changes suggesting impairment in RNA processing.
Article in European journal of histochemistry : EJH. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 48 citations in OpenAlex.
- Cultured myoblasts from patients affected by myotonic dystrophy type 2 exhibit senescence-related features: ultrastructural evidence.European journal of histochemistry : EJH · 2011Trial
- Aging in the Skeletal Muscle Revealed by Molecular Immunohistochemical Imaging.International journal of molecular sciences · 2025Review
- Molecular constraints of sarcopenia in the ageing muscle.Frontiers in aging · 2025Review
- Muscle fibre size and myonuclear positioning in trained and aged humans.Experimental physiology · 2024Article
- Sporadic Inclusion Body Myositis at the Crossroads between Muscle Degeneration, Inflammation, and Aging.International journal of molecular sciences · 2024Review
- Molecular and Structural Alterations of Skeletal Muscle Tissue Nuclei during Aging.International journal of molecular sciences · 2024Review
- Article
- Histochemistry for nucleic acid research: 60 years in the European Journal of Histochemistry.European journal of histochemistry : EJH · 2022Review
- Age-Related Changes in the Matrisome of the Mouse Skeletal Muscle.International journal of molecular sciences · 2021Article
- Age-dependent changes in nuclear-cytoplasmic signaling in skeletal muscle.Experimental gerontology · 2021Article
- Myonuclear content and domain size in small versus larger muscle fibres in response to 12 weeks of resistance exercise training in older adults.Acta physiologica (Oxford, England) · 2021Article
- Ultrastructural immunocytochemistry shows impairment of RNA pathways in skeletal muscle nuclei of old mice: A link to sarcopenia?European journal of histochemistry : EJH · 2021Article
- Age-dependent stress response DNA demethylation and gene upregulation accompany nuclear and skeletal muscle remodeling following acute resistance-type exercise in rats.Facets (Ottawa) · 2020Article
- Article
- Ultrastructural histochemistry in biomedical research: Alive and kicking.European journal of histochemistry : EJH · 2018Article
- Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4.Skeletal muscle · 2016Article
- Adapted physical exercise enhances activation and differentiation potential of satellite cells in the skeletal muscle of old mice.Journal of anatomy · 2016Article
- Muscle quality in aging: a multi-dimensional approach to muscle functioning with applications for treatment.Sports medicine (Auckland, N.Z.) · 2015Review
- Premature senescence in primary muscle cultures of myotonic dystrophy type 2 is not associated with p16 induction.European journal of histochemistry : EJH · 2014Article
- RNA Transcription and Maturation in Skeletal Muscle Cells are Similarly Impaired in Myotonic Dystrophy and Sarcopenia: The Ultrastructural Evidence.Frontiers in aging neuroscience · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advancing adult age is associated with a progressive decrease in skeletal muscle mass, strength and quality known as sarcopenia. The mechanisms underlying age-related skeletal muscle wasting and weakness are manifold and still remain to be fully elucidated. Despite the increasing evidence that the progress of muscle diseases leading to muscle atrophy/dystrophy may be related to defective RNA processing, no data on the morpho-functional features of skeletal muscle nuclei in sarcopenia are available at present. In this view, we have investigated, by combining morphometry and immunocytochemistry at light and electron microscopy, the fine structure of myonuclei as well as the distribution and amount of RNA processing factors in skeletal myofibres of biceps brachii and quadriceps femoris from adult and old rats. Results demonstrate that the myonuclei of aged type II fibres show an increased amount of condensed chromatin and lower amounts of phosphorylated polymerase II and DNA/RNA hybrid molecules, clearly indicating a decrease in pre-mRNA transcription rate compared to adult animals. In addition, myonuclei of aged fibres show decreased amounts of nucleoplasmic splicing factors and an accumulation of cleavage factors, polyadenilated RNA and perichromatin granules, suggesting a reduction in the processing and transport rate of premRNA. During ageing, it seems therefore that in rat myonuclei the entire production chain of mRNA, from synthesis to cytoplasmic export, is less efficient. This failure likely contributes to the reduced responsiveness of muscle cells to anabolic stimuli in the elderly.
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