ArticleEuropean journal of histochemistry : EJH
Immunohistochemical localization of glucagon and pancreatic polypeptide on rat endocrine pancreas: coexistence in rat islet cells.
Article in European journal of histochemistry : EJH. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Revealing the biological features of the axolotl pancreas as a new research model.Frontiers in cell and developmental biology · 2025Article
- Article
- Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production.Nature communications · 2021Article
- Differentiation of Human Deceased Donor, Adipose-Derived, Mesenchymal Stem Cells into Functional Beta Cells.Journal of stem cells & regenerative medicine · 2020Article
- AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells.Scientific reports · 2019Article
- MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic α CellsMolecular and cellular biology · 2018Article
- GcgDiabetologia · 2017Article
- Histochemistry through the years, browsing a long-established journal: novelties in traditional subjects.European journal of histochemistry : EJH · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used immunofluorescence double staining method to investigate the cellular localization of glucagon and pancreatic polypeptide (PP) in rat pancreatic islets. The results showed that both A-cells (glucagon-secreting cells) and PP-cells (PP-secreting cells) were located in the periphery of the islets. However, A-cells and PP-cells had a different regional distribution. Most of A-cells were located in the splenic lobe but a few of them were in the duodenal lobe of the pancreas. In contrast, the majority of PP-cells were found in the duodenal lobe and a few of them were in the splenic lobe of the pancreas. Furthermore, we found that 67.74% A-cells had PP immunoreactivity, 70.92% PP-cells contained glucagon immunoreactivity with immunofluorescence double staining. Our data support the concept of a common precursor stem cell for pancreatic hormone-producing cells.
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