ArticleThe Journal of urology2009
Anti-adhesive coating and clearance of device associated uropathogenic Escherichia coli cystitis.
Article in The Journal of urology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Development and Characterization of a Probe Device toward Intracranial Spectroscopy of Traumatic Brain Injury.ACS biomaterials science & engineering · 2021Article
- Catechol-Based Antimicrobial Polymers.Molecules (Basel, Switzerland) · 2021Review
- Evaluation of Polyethylene Glycol-Based Antimicrobial Coatings on Urinary Catheters in the Prevention ofJournal of endourology · 2021Article
- Mussel-inspired bioadhesives in healthcare: design parameters, current trends, and future perspectives.Biomaterials science · 2020Review
- Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications.Chemical Society reviews · 2020Article
- Rapidly responsive smart adhesive-coated micropillars utilizing catechol-boronate complexation chemistry.Soft matter · 2019Article
- Application of Novel 3,4-Dihydroxyphenylalanine-Containing Antimicrobial Polymers for the Prevention of Uropathogen Attachment to Urinary Biomaterials.Journal of endourology · 2019Article
- A biocompatible sol-gel derived titania coating for medical implants with antibacterial modification by copper integration.AMB Express · 2018Article
- Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein.Journal of polymer science. Part A, Polymer chemistry · 2017Review
- pH Responsive and Oxidation Resistant Wet Adhesive based on Reversible Catechol-Boronate Complexation.Chemistry of materials : a publication of the American Chemical Society · 2016Article
- Ureteral stent technology: Drug-eluting stents and stent coatings.Asian journal of urology · 2015Review
- Monitoring the Long-Term Degradation Behavior of Biomimetic Bioadhesive Using Wireless Magnetoelastic Sensor.IEEE transactions on bio-medical engineering · 2015Article
- Hydrogen peroxide generation and biocompatibility of hydrogel-bound mussel adhesive moiety.Acta biomaterialia · 2015Article
- Effect of nitro-functionalization on the cross-linking and bioadhesion of biomimetic adhesive moiety.Biomacromolecules · 2015Article
- Ambivalent Adhesives: Combining Biomimetic Cross-Linking With Antiadhesive Oligo(ethylene glycol).Macromolecules · 2012Article
- Polymer composition and substrate influences on the adhesive bonding of a biomimetic, cross-linking polymer.Journal of the American Chemical Society · 2012Article
- Mussel-Inspired Adhesives and Coatings.Annual review of materials research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeA previous study showed decreased uropathogen adherence using a novel anti-fouling coating consisting of mussel adhesive protein mimics conjugated to poly(ethylene glycol). We assessed the ability of methoxy polyethylene glycol-dihydroxyphenylalanine (Nerites Corp. Ltd., Madison, Wisconsin) coated ureteral stents to resist bacterial adherence, infection development and encrustation in a rabbit model of uropathogenic Escherichia coli cystitis. MATERIALS AND
methodsSof-Flex stent curls that were uncoated and coated with 3 coatings, including Surphys 002, 008 and 009, respectively, and uncoated Percuflex Plus stents were inserted transurethrally into the bladder of 50 male New Zealand White rabbits (Charles River Laboratories, Montreal, Quebec, Canada), followed by instillation of uropathogenic E. coli strain GR12 (10(7) cfu). Urine was examined for bacteria on days 0, 1, 3 and 7, and for cytokine levels on day 7. On day 7 the animals were sacrificed. Stent curls and bladders were harvested for analysis. In a parallel experiment stents were challenged in vitro for 7 days with GR12 in human urine.
resultsSurphys 009 coated devices showed decreased urine and stent bacterial counts compared to those in controls. Eight of 10 rabbits in the Surphys 009 group had sterile urine by day 3 vs 1 in each control group (p = 0.013), while stent adherent organisms were decreased by more than 75%. While no statistical differences were found in encrustation and bladder inflammation across the groups, immune scoring was lowest in the uncoated Sof-Flex control and Surphys 009 groups (p = 0.030).
conclusionsSurphys 009 strongly resisted bacterial attachment, resulting in improved infection clearance over that of uncoated devices. However, this did not translate to decreased encrustation, which appeared to be independent of infection in this model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.