ArticleBiophysical journal1990
Rapid activation, desensitization, and resensitization of synaptic channels of crayfish muscle after glutamate pulses.
Article in Biophysical journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 93 citations in OpenAlex.
- A fast solution switching system with temperature control for single cell measurements.Journal of neuroscience methods · 2011Article
- Glutamate transporter-mediated glutamate secretion in the mammalian pineal gland.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Inverse relationship between release probability and readily releasable vesicles in depressing and facilitating synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Regulation of kinetic properties of GluR2 AMPA receptor channels by alternative splicing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Depolarization increases the single-channel conductance and the open probability of crayfish glutamate channels.Biophysical journal · 1998Article
- Desensitization and resensitization kinetics of glutamate receptor channels from Drosophila larval muscle.Biophysical journal · 1997Article
- Activation kinetics of glutamate receptor channels from wild-type Drosophila muscle.Pflugers Archiv : European journal of physiology · 1996Article
- Kinetics of homomeric GluR6 glutamate receptor channels.Biophysical journal · 1996Article
- Open channel and competitive block of the embryonic form of the nicotinic receptor of mouse myotubes by (+)-tubocurarine.The Journal of physiology · 1996Article
- Glutamate responses of bipolar cells in a slice preparation of the rat retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- A molecular scheme for the reaction between gamma-aminobutyric acid and the most abundant chloride channel on crayfish deep extensor abdominal muscle.Pflugers Archiv : European journal of physiology · 1996Article
- Proton-activated currents in chick spinal motoneurons.Journal of comparative physiology. A, Sensory, neural, and behavioral physiology · 1995Article
- A novel method for incorporation of ion channels into a planar phospholipid bilayer which allows solution changes on a millisecond timescale.Pflugers Archiv : European journal of physiology · 1995Article
- GABAergic inhibition of crayfish deep extensor abdominal muscle exhibits a steep dose-response relationship and a high degree of cooperativity.Pflugers Archiv : European journal of physiology · 1995Article
- A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms.The Journal of physiology · 1994Article
- Cyclic nucleotide- and inositol phosphate-gated ion channels in lobster olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus.The Journal of physiology · 1993Article
- Rapid application and removal of second messengers to cyclic nucleotide-gated channels from olfactory epithelium.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Gating kinetics of the quisqualate-sensitive glutamate receptor of locust muscle studied using agonist concentration jumps and computer simulations.Biophysical journal · 1993Article
- A molecular scheme for the reaction between acetylcholine and nicotinic channels.Biophysical journal · 1993Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Completely desensitizing excitatory channels were activated in outside-out patches of crayfish muscle membrane by applying glutamate pulses with switching times of approximately 0.2 ms for concentration changes. Channels were almost completely activated with 10 mM glutamate. Maximum activation was reached within 0.4 ms with greater than or equal to 1 mM glutamate. Channel open probability decayed with a time constant of desensitization of 2 ms with 10 mM glutamate and more rapidly at lower glutamate concentrations. The rate of beginnings of bursts (average number of beginnings of bursts per time bin) decayed even faster but approximately in proportion to the glutamate concentration. The dose-response curve for the channel open probability and for the rate of bursts had a maximum double-logarithmic slope of 5.1 and 4.2, respectively. Channels desensitized completely without opening at very low or slowly rising glutamate concentrations. Desensitization thus originates from a closed channel state. Resensitization was tested by pairs of completely desensitizing glutamate pulses. Sensitivity to the second pulse returned rapidly at pulse intervals between 1 and 2 ms and was almost complete with an interval of 3 ms. Schemes of channel activation by up to five glutamate binding steps, with desensitization by glutamate binding from closed states, are discussed. At high agonist concentrations bursts are predominantly terminated by desensitization. Quantal currents are generated by pulses of greater than 1 mM glutamate, and their decay is determined by the duration of presence of glutamate and possibly by desensitization.
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