ArticleJournal of molecular biology2009
Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms.
Article in Journal of molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Antibodies targeting a shared epitope exploit IgE allostery to drive distinct functional outcomes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural and Functional Insights Into IgE Receptor Interactions and Disruptive Inhibition.Immunological reviews · 2025Review
- Hapten-Decorated DNA Nanostructures Decipher the Antigen-Mediated Spatial Organization of Antibodies Involved in Mast Cell Activation.ACS nano · 2023Article
- Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex.Nature communications · 2021Article
- Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.Acta crystallographica. Section F, Structural biology communications · 2020Article
- The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab.Nature communications · 2020Article
- IgE Antibodies: From Structure to Function and Clinical Translation.Antibodies (Basel, Switzerland) · 2019Review
- Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.Scientific reports · 2018Article
- Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction.Nature communications · 2018Article
- Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.Biochimica et biophysica acta. Proteins and proteomics · 2017Article
- Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.The Journal of biological chemistry · 2017Article
- IgE binds asymmetrically to its B cell receptor CD23.Scientific reports · 2017Article
- B Cell Intrinsic Mechanisms Constraining IgE Memory.Frontiers in immunology · 2017Review
- Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange.Nature communications · 2016Article
- Human immunoglobulin E flexes between acutely bent and extended conformations.Nature structural & molecular biology · 2014Article
- A novel structural unit in the N-terminal region of filamins.The Journal of biological chemistry · 2014Article
- A range of Cℇ3-Cℇ4 interdomain angles in IgE Fc accommodate binding to its receptor CD23.Acta crystallographica. Section F, Structural biology communications · 2014Article
- Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.Molecular immunology · 2013Article
- Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E.The Journal of biological chemistry · 2013Article
- A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E-receptor interactions.Analytical biochemistry · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The structure of immunoglobulin E (IgE)-Fc(3-4) has been solved in three new crystal forms, providing 13 snapshots of the Fc conformation and revealing a diverse range of open-closed motions among subunit chains and dimers. A more detailed analysis of the open-to-closed motion of IgE-Fc(3-4) was possible with so many structures, and the new structures allow a more thorough examination of the flexibility of IgE-Fc and its implications for receptor binding. The existence of a hydrophobic pocket at the elbow region of the Fc appears to be conformation dependent and suggests a means of regulating the IgE-Fc conformation (and potentially receptor binding) with small molecules.
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Registered trials
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