ReviewJournal of autoimmunity
Application of tissue-specific NK and NKT cell activity for tumor immunotherapy.
Review in Journal of autoimmunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- The emerging role of dendritic cells in the tumor microenvironment: from antigen presentation to targeted immunotherapy.Cell death & disease · 2025Review
- Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease.European journal of medical research · 2025Article
- New insights into iNKT cells and their roles in liver diseases.Frontiers in immunology · 2022Review
- Cross Talk Between Natural Killer T and Dendritic Cells and Its Impact on T Cell Responses in Infections.Frontiers in immunology · 2022Review
- Recent Advances: The Imbalance of Immune Cells and Cytokines in the Pathogenesis of Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland) · 2020Review
- Article
- Effect of cytokine-induced killer cells on immune function in patients with lung cancer.Oncology letters · 2016Article
- Immunology of hepatocellular carcinoma.World journal of hepatology · 2015Review
- Article
- Cell transfer therapy for cancer: past, present, and future.Journal of immunology research · 2014Review
- Role of lymphocytes in liver cancer.Oncoimmunology · 2013Review
- Fine tuning a well-oiled machine: Influence of NK1.1 and NKG2D on NKT cell development and function.International immunopharmacology · 2013Review
- NK cell-based immunotherapy for malignant diseases.Cellular & molecular immunology · 2013Review
- Selenium nanoparticle-enriched Lactobacillus brevis causes more efficient immune responses in vivo and reduces the liver metastasis in metastatic form of mouse breast cancer.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
- Natural killer cells in liver disease.Hepatology (Baltimore, Md.) · 2013Review
- The antitumor effect of the toll-like receptor 3 ligand polyinosinic-cytidylic acid as an adjuvant.Cancer immunology, immunotherapy : CII · 2013Article
- Novel molecular, cytotoxical, and immunological study on promising and selective anticancer activity of mung bean sprouts.BMC complementary and alternative medicine · 2012Article
- Immunoregulation of hepatitis B virus infection--rationale and clinical application.Nagoya journal of medical science · 2012Review
- Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer.Carcinogenesis · 2011Article
- A contemporary update on scleroderma.Clinical reviews in allergy & immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Natural killer (NK) and NKT cells are a first line of defense against pathogens and transformed cells. However, dysregulation of their function can lead to autoimmune disease. A better understanding of the mechanisms controlling NK and NKT effector function should lead to the development of improved strategies for the treatment of many diseases. The site in which NK and NKT cells reside should be taken into account, because accumulating evidence suggests that the tissue microenvironment strongly influences their function. In this regard, the liver represents a unique immunologic organ in which the balance between the need for tolerance and the ability to respond rapidly to pathogens and tissue injury is tightly regulated. NK cells in the liver have augmented cytolytic activity as compared to other organs, which is consistent with a role for liver-associated NK cells in being critical effector cells for inhibiting tumor metastasis in the liver. Several studies also suggest that hepatic NKT cells have different functions than those in other organs. Whereas splenic and thymic NKT cells have been shown to suppress diabetes development, facilitate the induction of systemic tolerance and are regulated by IL-4 and other Th2 cytokines, certain subsets of NKT cells in the liver are important sources of Th1 cytokines such as Interferon gamma, and are the primary mediators of anti-tumor responses. The unique properties and roles as critical effector cells make NK and NKT cells within the liver microenvironment attractive targets of immunotherapeutic approaches that have the goal of controlling tumor metastasis in the liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.