ReviewHormones and behavior2009
New tricks by an old dogma: mechanisms of the Organizational/Activational Hypothesis of steroid-mediated sexual differentiation of brain and behavior.
Review in Hormones and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 157 citations in OpenAlex.
- Effects of TBBPA Exposure on Neurodevelopment and Behavior in Mice.International journal of molecular sciences · 2025Article
- Interplay of polymorphisms in sex hormone receptors and facial sexual differentiation in shaping prosocial behavior.Scientific reports · 2025Article
- More similarity than difference: comparison of within- and between-sex variance in early adolescent brain structure.Research square · 2024Article
- Regrettable Substitutes and the Brain: What Animal Models and Human Studies Tell Us about the Neurodevelopmental Effects of Bisphenol, Per- and Polyfluoroalkyl Substances, and Phthalate Replacements.International journal of molecular sciences · 2024Review
- Sex diversity in the 21st century: Concepts, frameworks, and approaches for the future of neuroendocrinology.Hormones and behavior · 2024Article
- Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.Nature neuroscience · 2023Article
- The Curious Case of the Naked Mole-Rat: How Extreme Social and Reproductive Adaptations Might Influence Sex Differences in the Brain.Current topics in behavioral neurosciences · 2023Article
- Developmental nicotine exposure and masculinization of the rat preoptic area.Neurotoxicology · 2022Article
- Large-Scale Transcriptomics Studies Provide Insight Into Sex Differences in Depression.Biological psychiatry · 2022Review
- REPRODUCTIVE TOXICOLOGY: Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways.Reproduction (Cambridge, England) · 2021Review
- Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain.Communications biology · 2021Article
- Autism Spectrum Disorder Genetics and the Search for Pathological Mechanisms.The American journal of psychiatry · 2021Review
- Epigenetic Regulation and Environmental Sex Determination in Cichlid Fishes.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2021Review
- Testosterone and the brain: from cognition to autism.Physiological research · 2020Review
- Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective.Journal of the Endocrine Society · 2020Article
- Sexual Differentiation and Substance Use: A Mini-Review.Endocrinology · 2020Review
- Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Gonadal hormone-independent sex differences in GABABritish journal of pharmacology · 2020Article
- Microglial and Astrocytic Function in Physiological and Pathological Conditions: Estrogenic Modulation.International journal of molecular sciences · 2020Review
- Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats.Neurotoxicology · 2019Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The hormonal regulation of sexual behavior has been the topic of study for over 50 years and yet controversies persist regarding the importance of early versus late events and the identity of the critical neural and cellular substrates. We have taken a mechanistic approach toward the masculinizing actions of the gonadal steroid estradiol, as a means to understand how organization of the neuroarchitechture during a perinatal sensitive period exerts enduring influences on adult behavior. We have identified important roles for prostaglandins, FAK and paxillin, PI3 kinase and glutamate, and determined that cell-to-cell signaling is a critical component of the early organizational events. We have further determined that the mechanisms mediating different components of sexual behavior are distinct and regionally specific. The multitude of mechanisms by which the steroid estradiol, exerts divergent effects on the developing nervous system provides for a multitude of phenotypes which can vary significantly both within and between the sexes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.