ArticleParticle and fibre toxicology2009
Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection.
Article in Particle and fibre toxicology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Diesel exposure suppresses natural killer cell function and resolution of eosinophil inflammation: a randomized controlled trial of exposure in allergic rhinitics.Particle and fibre toxicology · 2016Trial
- Diesel exhaust exposure and nasal response to attenuated influenza in normal and allergic volunteers.American journal of respiratory and critical care medicine · 2012Trial
- Impact of inhaled pollutants on response to viral infection in controlled exposures.The Journal of allergy and clinical immunology · 2021Review
- Single-walled carbon nanotubes repress viral-induced defense pathways through oxidative stress.Nanotoxicology · 2019Article
- Single-walled carbon nanotubes modulate pulmonary immune responses and increase pandemic influenza a virus titers in mice.Virology journal · 2017Article
- Comment on "Long-Term Effects of Diesel Exhaust Particles on Airway Inflammation and Remodeling in a Mouse Model" by Kim et al.Allergy, asthma & immunology research · 2017Article
- Nanoparticles modulate surfactant protein A and D mediated protection against influenza A infection in vitro.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Diesel exhaust particles modify natural killer cell function and cytokine release.Particle and fibre toxicology · 2013Article
- Influenza enhances caspase-1 in bronchial epithelial cells from asthmatic volunteers and is associated with pathogenesis.The Journal of allergy and clinical immunology · 2012Article
- Carbon nanotubes as delivery systems for respiratory disease: do the dangers outweigh the potential benefits?Expert review of respiratory medicine · 2011Review
- Jet exhaust particles alter human dendritic cell maturation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Role of oxidative stress on diesel-enhanced influenza infection in mice.Particle and fibre toxicology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundViral infections and exposure to oxidant air pollutants are two of the most important inducers of asthma exacerbation. Our previous studies have demonstrated that exposure to diesel exhaust increases the susceptibility to influenza virus infections both in epithelial cells in vitro and in mice in vivo. Therefore, we examined whether in the setting of allergic asthma, exposure to oxidant air pollutants enhances the susceptibility to respiratory virus infections, which in turn leads to increased virus-induced exacerbation of asthma. Ovalbumin-sensitized (OVA) male C57BL/6 mice were instilled with diesel exhaust particles (DEP) or saline and 24 hours later infected with influenza A/PR/8. Animals were sacrificed 24 hours post-infection and analyzed for markers of lung injury, allergic inflammation, and pro-inflammatory cytokine production.
resultsExposure to DEP or infection with influenza alone had no significant effects on markers of injury or allergic inflammation. However, OVA-sensitized mice that were exposed to DEP and subsequently infected with influenza showed increased levels of eosinophils in lung lavage and tissue. In addition Th2-type cytokines, such as IL-4 and IL-13, and markers of eosinophil chemotaxis, such as CCL11 and CCR3, were increased in OVA-sensitized mice exposed to DEP prior to infection with influenza. These mice also showed increased levels of IL-1alpha, but not IL-10, RANTES, and MCP-1 in lung homogenates.
conclusionThese data suggest that in the setting of allergic asthma, exposure to diesel exhaust could enhance virus-induced exacerbation of allergic inflammation.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.