ArticleMolecular microbiology2009
Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae.
Article in Molecular microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters.Cell communication and signaling : CCS · 2024Article
- Eukaryotic mRNA decapping factors: molecular mechanisms and activity.The FEBS journal · 2023Review
- Article
- Determinants of the temperature adaptation of mRNA degradation.Nucleic acids research · 2022Article
- Translation machinery reprogramming in programmed cell death in Saccharomyces cerevisiae.Cell death discovery · 2021Article
- How Cancer Exploits Ribosomal RNA Biogenesis: A Journey beyond the Boundaries of rRNA Transcription.Cells · 2019Review
- Decapping enzymes STOP "cancer" ribosomes in their tracks.The EMBO journal · 2018Article
- mRNA decapping: finding the right structures.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- P-bodies and stress granules: possible roles in the control of translation and mRNA degradation.Cold Spring Harbor perspectives in biology · 2012Review
- RNA degradation in Saccharomyces cerevisae.Genetics · 2012Review
- Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Microbiology and molecular biology reviews : MMBR · 2012Review
- IRES-Dependent Translational Control during Virus-Induced Endoplasmic Reticulum Stress and Apoptosis.Frontiers in microbiology · 2012Article
- mTOR signaling in protein homeostasis: less is more?Cell cycle (Georgetown, Tex.) · 2011Review
- PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation.The Journal of biological chemistry · 2011Article
- Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition.RNA (New York, N.Y.) · 2011Article
- Evidence for divergent evolution of growth temperature preference in sympatric Saccharomyces species.PloS one · 2011Article
- 5' to 3' mRNA decay factors colocalize with Ty1 gag and human APOBEC3G and promote Ty1 retrotransposition.Journal of virology · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In mammalian and Drosophila cells, heat stress strongly reduces general protein translation while activating cap-independent translation mechanisms to promote the expression of stress-response proteins. In contrast, in Saccharomyces cerevisiae general translation is only mildly and transiently reduced by heat stress and cap-independent translation mechanisms have not been correlated with the heat stress response. Recently we have identified direct target genes of the heat shock transcription factor (HSF), including genes encoding proteins thought to be important for general translation. One gene activated by HSF during heat stress encodes the enhancer of decapping protein, Edc2, previously shown to enhance mRNA decapping under conditions when the decapping machinery is limited. In this report we show that strains lacking Edc2, as well as the paralogous protein Edc1, are compromised for growth under persistent heat stress. This growth deficiency can be rescued by expression of a mutant Edc1 protein deficient in mRNA decapping indicative of a decapping independent function during heat stress. Yeast strains lacking Edc1 and Edc2 are also sensitive to the pharmacological inhibitor of translation paromomycin and exposure to heat stress and paromomycin functions synergistically to reduce yeast viability, suggesting that in the absence of Edc1 and Edc2 translation is compromised under heat stress conditions. Strains lacking Edc1 and Edc2 have significantly reduced rates of protein translation during growth under heat stress conditions, but not under normal growth conditions. We propose that Edc1 and the stress responsive isoform Edc2 play important roles in protein translation during stress.
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