ReviewJournal of neurochemistry2009
Penelope's web: using alpha-latrotoxin to untangle the mysteries of exocytosis.
Review in Journal of neurochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- The Dissociation of Latrophilin Fragments by Perfluorooctanoic Acid (PFOA) Inhibits LTXToxins · 2025Article
- Article
- High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms.Toxicon: X · 2024Article
- Human antibodies neutralizing the alpha-latrotoxin of the European black widow.Frontiers in immunology · 2024Article
- Molecular architecture of black widow spider neurotoxins.Nature communications · 2021Article
- Alternative Transcription at Venom Genes and Its Role as a Complementary Mechanism for the Generation of Venom Complexity in the Common House Spider.Frontiers in ecology and evolution · 2019Article
- Catching Latrophilin With Lasso: A Universal Mechanism for Axonal Attraction and Synapse Formation.Frontiers in neuroscience · 2019Review
- A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis.Acta neuropathologica communications · 2018Article
- The Mechanism of Regulated Release of Lasso/Teneurin-2.Frontiers in molecular neuroscience · 2016Article
- Review
- Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis.Journal of neurochemistry · 2015Article
- Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics.BMC genomics · 2014Article
- Glutamatergic modulation of synaptic-like vesicle recycling in mechanosensory lanceolate nerve terminals of mammalian hair follicles.The Journal of physiology · 2013Article
- Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.Frontiers in cellular neuroscience · 2013Article
- δ/ω-Plectoxin-Pt1a: an excitatory spider toxin with actions on both Ca(2+) and Na(+) channels.PloS one · 2013Article
- High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research.BMC neuroscience · 2012Article
- Ion channels and receptor as targets for the control of parasitic nematodes.International journal for parasitology. Drugs and drug resistance · 2011Review
- Alpha-latrotoxin rescues SNAP-25 from BoNT/A-mediated proteolysis in embryonic stem cell-derived neurons.Toxins · 2011Article
- From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- The latrophilins, "split-personality" receptors.Advances in experimental medicine and biology · 2010Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
For more than three decades, the venom of the black widow spider and its principal active components, latrotoxins, have been used to induce release of neurotransmitters and hormones and to study the mechanisms of exocytosis. Given the complex nature of alpha--latrotoxin (alpha-LTX) actions, this research has been continuously overshadowed by many enigmas, misconceptions and perpetual changes of the underlying hypotheses. Some of the toxin's mechanisms of action are still not completely understood. Despite all these difficulties, the extensive work of several generations of neurobiologists has brought about a great deal of fascinating insights into pre-synaptic processes and has led to the discovery of several novel proteins and synaptic systems. For example, alpha-LTX studies have contributed to the widespread acceptance of the vesicular theory of transmitter release. Pre-synaptic receptors for alpha-LTX--neurexins, latrophilins and protein tyrosine phosphatase sigma--and their endogenous ligands have now become centrepieces of their own areas of research, with a potential of uncovering new mechanisms of synapse formation and regulation that may have medical implications. However, any future success of alpha-LTX research will require a better understanding of this unusual natural tool and a more precise dissection of its multiple mechanisms.
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Registered trials
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