Evidence map›Paper›PMID 19682111›Full record

Trial reportJournal of the American Geriatrics Society2009

Use of the late-life function and disability instrument to assess disability in major depression.

Jordan F Karp, Elizabeth Skidmore, Meredith Lotz, Eric Lenze, Mary Amanda Dew, Charles F Reynolds

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01124188 (Optimizing Care for Older Adults With Back Pain and Depression), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01124188 phase4completednot on this mapstarted 2010, after this paper: background citation

Optimizing Care for Older Adults With Back Pain and Depression

TypeinterventionalSponsorUniversity of PittsburghRan2010 to 2016Enrolled263ConditionsDepression, Back PainArmsHigher-dose venlafaxine, Supportive management, Problem Solving Therapy for Depression and Pain
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Frequency of But Not Capacity for Participation in Everyday Activities Is Associated With Cognitive Impairment in Late Life.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Depression and its correlates in older adults in Ukraine.International journal of geriatric psychiatry · 2011
    Article
  17. Article
  18. The burden of late-life generalized anxiety disorder: effects on disability, health-related quality of life, and healthcare utilization.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2009
    Article
  19. Review
  20. A Need to Activate Lasting Engagement.The American journal of occupational therapy : official publication of the American Occupational Therapy Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jordan F KarpAdvanced Center for Intervention and Services Research for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Courier/Office: 100 North Bellefield Avenue, Room 766, Pittsburgh, PA 15213, USA. karpjf@upmc.edu
Elizabeth Skidmore
Meredith Lotz
Eric Lenze
Mary Amanda Dew
Charles F Reynolds
UPMC Health System · US

Funding

University of Pittsburgh Clinical and Translational Science InstitutionKL2RR024154 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$22.2M
University of Pittsburgh Clinical and Translational Science InstitutionKL2TR000146 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$8.7M
Research Network Development Core (pages 329-374)P30MH071944 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F. · 2005 to 2009
$6.7M
GERIATRIC DEPRESSION--NEUROBIOLOGY OF TREATMENTR01MH037869 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F. · 1985 to 2008
$5.8M
Pathways Linking Late-Life Depression to MCI &DementiaR01MH072947 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUTTERS, MERYL A · 2005 to 2009
$2.0M
MAINTENANCE THERAPIES IN LATE-LIFE DEPRESSIONR37MH043832 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F · 1989 to 1998
–
NCATS NIH HHS KL2 TR000146NCRR NIH HHS KL2 RR024154NCRR NIH HHS KL2 RR024154-03NIMH NIH HHS P30 MH071944NIMH NIH HHS R01 MH037869NIMH NIH HHS R01 MH072947NIMH NIH HHS R01 MH37869NIMH NIH HHS R37 MH043832NIMH NIH HHS R37 MH43832
6 · The paper itself

Abstract

objectivesTo determine whether there was greater disability in subjects with depression than in those without, the correlation between disability and depression severity and quality of life, and whether improvement in disability after antidepressant pharmacotherapy was greater in those who responded to antidepressant treatment.

designDisability in subjects with and without depression from two different studies was compared for 22 weeks. Correlations were performed for the subjects with depression between disability and depression, anxiety, health-related quality of life (HRQOL), and medical comorbidity. T-tests were used to compare disability between subjects who did and did not respond to antidepressant treatment and change in disability after pharmacotherapy.

settingLate-life depression research clinic.

participantsThe 313 subjects were recruited from primary care and the community and were aged 60 and older; 244 subjects were participants in a depression treatment protocol, and 69 subjects without depression participated in a separate longitudinal observational study of the mental and cognitive health of depression-free older adults. MEASUREMENTS: The Late-Life Function and Disability Instrument (LL-FDI), a measure of instrumental activity of daily living, personal role, and social role functioning.

resultsSubjects with depression scored lower than controls for domains measuring limitation (can do) and frequency (does do) of activities. Both disability domains correlated with depression severity, anxiety, HRQOL, and cognition. Disability improved with antidepressant treatment; for partial responders who continued to receive higher-dose antidepressant treatment out to 22 weeks, there was continued improvement, although not to the level of comparison subjects without depression.

conclusionThe LL-FDI appears to discriminate subjects with depression from those without, correlates with depression severity, and demonstrates sensitivity to antidepressant treatment response. We recommend further investigation of the LL-FDI and similar disability instruments for assessing depression-related disability.

Indexed as

Disability EvaluationActivities of Daily LivingAgedAged, 80 and overAntidepressive Agents, Second-GenerationAnxiety DisordersCitalopramCognition DisordersCombined Modality TherapyComorbidityFemaleHumansLongitudinal StudiesMajor Depressive DisorderMaleMental Status ScheduleAntidepressive Agents, Second-GenerationCitalopram

Identifiers

PMID19682111
PMCPMC2854008
OpenAlexW1540568919

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.