ArticleBritish journal of pharmacology2009
Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney cancer cells by suppression of BAG3 expression.
Article in British journal of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Critical Role of Viral Protein Hexon in Hypervirulent Fowl Adenovirus Serotype-4-Induced Autophagy by Interaction with BAG3 and Promotion of Viral Replication in LMH Cells.Journal of virology · 2023Article
- MLN2238 exerts its anti-tumor effectsFrontiers in pharmacology · 2022Article
- BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and disease.American journal of physiology. Heart and circulatory physiology · 2021Article
- Advances in the role and mechanism of BAG3 in dilated cardiomyopathy.Heart failure reviews · 2021Review
- Review
- HIPK3 Mediates Inflammatory Cytokines and Oxidative Stress Markers in Monocytes in a Rat Model of Sepsis Through the JNK/c-Jun Signaling Pathway.Inflammation · 2020Article
- Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3.Oncology letters · 2019Article
- P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages.Frontiers in immunology · 2019Article
- Mechanism of the enhancing effects of miR-93 on resistance of breast cancer MCF-7 cells to adriamycin.Oncology letters · 2018Article
- Overexpression of the anti-apoptotic protein BAG3 in human choroidal melanoma: A case report.Oncology letters · 2017Article
- Bcl-2-associated athanogene 3 protects the heart from ischemia/reperfusion injury.JCI insight · 2016Article
- ERK-mediated phosphorylation of BIS regulates nuclear translocation of HSF1 under oxidative stress.Experimental & molecular medicine · 2016Article
- Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.The American journal of pathology · 2016Article
- Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells.Oncotarget · 2016Article
- BAG3 elevation inhibits cell proliferation via direct interaction with G6PD in hepatocellular carcinomas.Oncotarget · 2016Article
- BAG3 protects against hyperthermic stress by modulating NF-κB and ERK activities in human retinoblastoma cells.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- BAG3 regulates ECM accumulation in renal proximal tubular cells induced by TGF-β1.American journal of translational research · 2015Article
- BAG3 facilitates the clearance of endogenous tau in primary neurons.Neurobiology of aging · 2015Article
- Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney.American journal of translational research · 2015Article
- Development of a capillary electrophoresis platform for identifying inhibitors of protein-protein interactions.Analytical chemistry · 2013Article
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7 authors.
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Abstract
background and purposeProteasome inhibitors represent a novel class of anti-tumour agents that have clinical efficacy against haematological and solid cancers. The anti-apoptotic protein BAG3 is a member of the Bcl-2-associated athanogene family. We have previously shown that BAG3 is up-regulated after exposure to proteasome inhibitors and that inhibition of BAG3 sensitized cells to apoptosis induced by proteasome inhibition. However, the mechanisms by which proteasome inhibition induced BAG3 expression remained unclear and the present experiments were designed to elucidate these mechanisms. EXPERIMENTAL APPROACH: Effects of the proteasome inhibitor MG132 on activation of mitogenic signalling pathways were evaluated in kidney cancer cells (A498, Caki1, Caki2), with Western blotting. Specific inhibitors against individual mitogenic signalling pathways, real-time reverse transcription-polymerase chain reaction and luciferase reporter assays were used to investigate the roles of mitogenic signalling pathways in BAG3 induction after proteasome inhibition. Cell death was evaluated using Annexin V/propidium iodide staining and subsequent FACS. KEY
resultsMG132 activated several key mitogenic signalling pathways including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) activities. Induction of BAG3 by MG132 was inhibited by blocking JNK, but not ERK1/2 and p38 MAPK signalling pathways. In addition, SP600125 and dominant-negative JNK1 suppressed BAG3 promoter-driven reporter gene expression. Furthermore, activation of the JNK pathway induced BAG in kidney cancer cells after treatment with MG132. CONCLUSIONS AND IMPLICATIONS: Our results suggested that the JNK pathway was associated with the protective response against proteasome inhibition, by mediating induction of BAG3.
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