Evidence map›Paper›PMID 19681699›Full record

ReviewExpert review of anti-infective therapy2009

Current management of human granulocytic anaplasmosis, human monocytic ehrlichiosis and Ehrlichia ewingii ehrlichiosis.

Rachael J Thomas, J Stephen Dumler, Jason A Carlyon

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of anti-infective therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. mBio · 2026
    Article
  5. Review
  6. Article
  7. Simplified Spectrum Score (SScientific reports · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Tick-Borne Diseases of Humans and Animals in West Africa.Pathogens (Basel, Switzerland) · 2023
    Review
  12. Review
  13. Article
  14. Infectious disease reports · 2023
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Functional Characterization of MultipleInternational journal of molecular sciences · 2021
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Rachael J ThomasDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. rjthomas@vcu.edu
J Stephen Dumler
Jason A Carlyon
Virginia Commonwealth University · USJohns Hopkins Medicine · US

Funding

The roles of Anaplasma phagocytophilum surface proteins in infectionR01AI072683 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CARLYON, JASON A · 2007 to 2021
$5.8M
EHRLICHIA-GRANULOCYTE INTERACTIONS AND INFECTIONR01AI044102 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUMLER, JOHN STEPHEN · 2000 to 2019
$5.3M
The roles of Anaplasma phagocytophilum surface proteins in infectionR37AI072683 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI Jason A Carlyon · 2022 to 2026
$2.6M
NIAID NIH HHS R01 AI044102NIAID NIH HHS R01AI044102NIAID NIH HHS R01 AI072683NIAID NIH HHS R01AI072683NIAID NIH HHS R37 AI072683
6 · The paper itself

Abstract

Anaplasma phagocytophilum, Ehrlichia chaffeensis and Ehrlichia ewingii are emerging tick-borne pathogens and are the causative agents of human granulocytic anaplasmosis, human monocytic ehrlichiosis and E. ewingii ehrlichiosis, respectively. Collectively, these are referred to as human ehrlichioses. These obligate intracellular bacterial pathogens of the family Anaplasmataceae are transmitted by Ixodes spp. or Amblyomma americanum ticks and infect peripherally circulating leukocytes to cause infections that range in clinical spectra from asymptomatic seroconversion to mild, severe or, in rare instances, fatal disease. This review describes: the ecology of each pathogen; the epidemiology, clinical signs and symptoms of the human diseases that each causes; the choice methods for diagnosing and treating human ehrlichioses; recommendations for patient management; and is concluded with suggestions for potential future research.

Indexed as

Anaplasma phagocytophilumEhrlichiaEhrlichia chaffeensisAnimalsAnti-Bacterial AgentsArachnid VectorsDoxycyclineEhrlichiosisHumansIxodidaeMonocytesNeutrophilsAnti-Bacterial AgentsDoxycycline

Identifiers

PMID19681699
PMCPMC2739015
OpenAlexW2140330056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.