ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Gene expression profiles of lens regeneration and development in Xenopus laevis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Regulation of chromatin organization during animal regeneration.Cell regeneration (London, England) · 2023Review
- The miRNA-34a/Sirt1/p53 pathway in a rat model of lens regeneration.Annals of translational medicine · 2022Article
- Modeling ocular lens disease in Xenopus.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Studying In Vivo Retinal Progenitor Cell Proliferation in Xenopus laevis.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Using theFrontiers in physiology · 2019Article
- Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development.Epigenetics & chromatin · 2018Article
- Diverse Evolutionary Origins and Mechanisms of Lens Regeneration.Molecular biology and evolution · 2018Review
- Lens regeneration: a historical perspective.The International journal of developmental biology · 2018Review
- Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.Experimental eye research · 2016Article
- Retinoic acid regulation by CYP26 in vertebrate lens regeneration.Developmental biology · 2014Article
- The roles of endogenous retinoid signaling in organ and appendage regeneration.Cellular and molecular life sciences : CMLS · 2013Review
- Cell signaling pathways in vertebrate lens regeneration.Current topics in microbiology and immunology · 2013Review
- Patterns of gene expression in microarrays and expressed sequence tags from normal and cataractous lenses.Human genomics · 2012Article
- Ubiquitin-proteasome system components are upregulated during intestinal regeneration.Genesis (New York, N.Y. : 2000) · 2012Article
- Transdifferentiation from cornea to lens in Xenopus laevis depends on BMP signalling and involves upregulation of Wnt signalling.BMC developmental biology · 2011Article
- The expression of αA- and βB1-crystallin during normal development and regeneration, and proteomic analysis for the regenerating lens in Xenopus laevis.Molecular vision · 2011Article
- Molecular and cellular aspects of amphibian lens regeneration.Progress in retinal and eye research · 2010Article
- The G-protein-coupled receptor, GPR84, is important for eye development in Xenopus laevis.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Expression profiles during dedifferentiation in newt lens regeneration revealed by expressed sequence tags.Molecular vision · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Seven hundred and thirty-four unique genes were recovered from a cDNA library enriched for genes up-regulated during the process of lens regeneration in the frog Xenopus laevis. The sequences represent transcription factors, proteins involved in RNA synthesis/processing, components of prominent cell signaling pathways, genes involved in protein processing, transport, and degradation (e.g., the ubiquitin/proteasome pathway), matrix metalloproteases (MMPs), as well as many other proteins. The findings implicate specific signal transduction pathways in the process of lens regeneration, including the FGF, TGF-beta, MAPK, Retinoic acid, Wnt, and hedgehog signaling pathways, which are known to play important roles in eye/lens development and regeneration in various systems. In situ hybridization revealed that the majority of genes recovered are expressed during embryogenesis, including in eye tissues. Several novel genes specifically expressed in lenses were identified. The suite of genes was compared to those up-regulated in other regenerating tissues/organisms, and a small degree of overlap was detected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.