ReviewNeurochemical research2010
Oxidative mechanisms of brain dysfunction during sepsis.
Review in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Protective effect of exercise on animals with sepsis: a systematic review of the existing literature.BMC infectious diseases · 2025Pooled it
- Hyperoxia and brain: the link between necessity and injury from a molecular perspective.Neurotoxicity research · 2024Review
- Impact of Exercise Training on Survival Rate and Neural Cell Death in Sepsis Through the Maintenance of Redox Equilibrium.International neurourology journal · 2024Article
- Cerebral Glutamate Alterations Using Chemical Exchange Saturation Transfer Imaging in a Rat Model of Lipopolysaccharide-Induced Sepsis.Metabolites · 2023Article
- Diabetes Exacerbates Sepsis-Induced Neuroinflammation and Brain Mitochondrial Dysfunction.Inflammation · 2022Article
- Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis.Frontiers in immunology · 2022Review
- Microglial Activation Modulates Neuroendocrine Secretion During Experimental Sepsis.Molecular neurobiology · 2021Article
- Stanniocalcin 1 Inhibits the Inflammatory Response in Microglia and Protects Against Sepsis-Associated Encephalopathy.Neurotoxicity research · 2021Article
- Isoflurane reduces septic neuron injury by HO‑1‑mediated abatement of inflammation and apoptosis.Molecular medicine reports · 2021Article
- Emerging Role for Ferroptosis in Infectious Diseases.Advances in experimental medicine and biology · 2021Review
- Short Term Usage of Omega-3 Polyunsaturated Fatty Acids Ameliorate Lipopolysaccharide-Induced Inflammatory Response and Oxidative Stress in the Neonatal Rat Hippocampal Tissue.Frontiers in nutrition · 2020Article
- Pro-inflammatory activation of microglia in the brain of patients with sepsis.Neuropathology and applied neurobiology · 2019Article
- Design, synthesis and biological evaluation of hybrid nitroxide-based non-steroidal anti-inflammatory drugs.European journal of medicinal chemistry · 2018Article
- Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis.Molecular neurobiology · 2018Review
- P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction.Molecular neurobiology · 2017Article
- Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1.Scientific reports · 2016Article
- Interleukin-1 Receptor Antagonist Decreases Hypothalamic Oxidative Stress During Experimental Sepsis.Molecular neurobiology · 2016Article
- Betaine protects cerebellum from oxidative stress following levodopa and benserazide administration in rats.Iranian journal of basic medical sciences · 2015Article
- Beneficial antioxidant properties of betaine against oxidative stress mediated by levodopa/benserazide in the brain of rats.The journal of physiological sciences : JPS · 2015Article
- Effects of organoselenium compounds on early and late brain biochemical alterations in sepsis-survivor rats.Neurotoxicity research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress has drawn a lot of attention in the past few decades, since it has been reported to participate in the mechanism of many diseases. Therefore, it seemed to be a good rationale to aim oxidative stress on therapeutic research. Sepsis is a complex systemic syndrome characterized by an imbalance between pro- and anti-inflammatory responses to a pathogen; its pathophysiology is a dynamic process which involves components of the immune system, the coagulation pathway, parenchymal cells, and the endocrine and metabolic pathways. It is well characterized that oxidative stress plays a crucial role in sepsis development, but the relation between central nervous system dysfunction and oxidative stress during sepsis is not well understood. Thus, we here summarize the current knowledge on the role of free radicals in the development of brain dysfunction in sepsis focusing on oxidative damage and the redox control of brain inflammatory pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.