Trial reportEuropean journal of nutrition2010
Lupin protein compared to casein lowers the LDL cholesterol:HDL cholesterol-ratio of hypercholesterolemic adults.
Trial report in European journal of nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Pooled it
- Lupins and Health Outcomes: A Systematic Literature Review.Nutrients · 2022Pooled it
- Effects of plant protein and animal protein on lipid profile, body weight and body mass index on patients with hypercholesterolemia: a systematic review and meta-analysis.Acta diabetologica · 2020Pooled it
- Pooled it
- Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of the American Heart Association · 2017Pooled it
- Whey protein lowers blood pressure and improves endothelial function and lipid biomarkers in adults with prehypertension and mild hypertension: results from the chronic Whey2Go randomized controlled trial.The American journal of clinical nutrition · 2016Trial
- Lupin protein positively affects plasma LDL cholesterol and LDL:HDL cholesterol ratio in hypercholesterolemic adults after four weeks of supplementation: a randomized, controlled crossover study.Nutrition journal · 2013Trial
- Recent Advances in Plant-Based Dairy Alternatives: Technological Innovations, Nutritional Enhancement, Sustainability, and Consumer Perspectives.Food science & nutrition · 2026Review
- Effects of Non-Soy Legumes on Body Weight and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Food science & nutrition · 2026Review
- Recent Advances in the Therapeutic Potential of Bioactive Molecules from Plants of Andean Origin.Nutrients · 2025Review
- Metabolic Syndrome and Biotherapeutic Activity of Dairy (Cow and Buffalo) Milk Proteins and Peptides: Fast Food-Induced Obesity Perspective-A Narrative Review.Biomolecules · 2024Review
- Plant Proteins: Methods of Quality Assessment and the Human Health Benefits of Pulses.Foods (Basel, Switzerland) · 2023Review
- Animal versus plant-based protein and risk of cardiovascular disease and type 2 diabetes: a systematic review of randomized controlled trials and prospective cohort studies.Food & nutrition research · 2023Review
- How Healthy Are Non-Traditional Dietary Proteins? The Effect of Diverse Protein Foods on Biomarkers of Human Health.Foods (Basel, Switzerland) · 2022Review
- Animal and Plant Protein Sources and Cardiometabolic Health.Advances in nutrition (Bethesda, Md.) · 2019Review
- Isolated Conglutin γ from Lupin, but not Phytate, Lowers Serum Cholesterol Without Influencing Vascular Lesion Development in the ApoE-deficient Mouse Model.Plant foods for human nutrition (Dordrecht, Netherlands) · 2015Article
- Impact of functional foods on prevention of cardiovascular disease and diabetes.Current cardiology reports · 2015Review
- Additive effects of lupin protein and phytic acid on aortic calcification in ApoE deficient mice.Journal of clinical & translational endocrinology · 2015Article
- Lupin protein isolate versus casein modifies cholesterol excretion and mRNA expression of intestinal sterol transporters in a pig model.Nutrition & metabolism · 2014Article
- Effects of dairy protein and fat on the metabolic syndrome and type 2 diabetes.The review of diabetic studies : RDS · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLupin protein had hypocholesterolemic effects in laboratory animals. However, the effect in humans has not been elucidated till now. AIM OF THE STUDY: To investigate the effect of lupin protein on circulating cholesterol in plasma and lipoproteins of hypercholesterolemic subjects. SUBJECTS AND
methodsA randomised, double-blind, placebo-controlled, parallel trial (23 females and 20 males completed the trial) was conducted to compare the effects of lupin protein versus casein as control protein on plasma lipids and amino acids. Thirty-five grams of the test protein were consumed daily for 6 weeks.
resultsBoth lupin protein and casein resulted in a reduction of circulating plasma cholesterol (-0.50 +/- 0.64 and -0.47 +/- 0.79 mM; P < 0.05) from baseline to week 6. The reduction of plasma cholesterol was mainly caused by a reduction of LDL cholesterol in the lupin protein group (-0.31 +/- 0.46 mM; P < 0.05), while in the casein group HDL cholesterol significantly declined (-0.17 +/- 0.15 mM; P < 0.05). Comparing the lupin protein group with the casein group yielded a difference in the net changes from baseline to week 6 in the LDL:HDL cholesterol-ratio of -0.24 (95% CI: -0.007, -0.479; P < 0.05). No significant differences in net changes were observed for plasma concentrations of triglycerides, glucose, homocysteine, taurine and most of the amino acids.
conclusionsLupin protein compared to casein slightly lowered the concentration of LDL cholesterol in hypercholesterolemic subjects, without altering HDL cholesterol. No or minor effects of lupin protein were observed on circulating glucose, homocysteine and plasma amino acids.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.