Trial reportEuropean journal of applied physiology2009
Isometric handgrip exercise improves acute neurocardiac regulation.
Trial report in European journal of applied physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04467879 (A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Correlation properties of heart rate variability during endurance exercise: A systematic review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2020Pooled it
- Sex differences in beat-to-beat blood pressure variability following isometric handgrip exercise.European journal of applied physiology · 2026Trial
- Post-dynamic, isometric and combined resistance exercise responses in medicated hypertensive men.Journal of human hypertension · 2024Trial
- Effects of isometric handgrip training dose on resting blood pressure and resistance vessel endothelial function in normotensive women.European journal of applied physiology · 2013Trial
- Effect of short-term isometric handgrip training on blood pressure in middle-aged females.Cardiovascular journal of AfricaTrial
- Assessment of the cardiac vagal reflex: validation of the 4-s exercise test during simulated wheelchair propulsion.European journal of applied physiology · 2026Article
- Impact of muscle echo intensity on post-exercise blood pressure response in older normotensive and hypertensive females: Pilot study.Physiological reports · 2022Article
- Acute cardiac autonomic and haemodynamic responses to leg and arm isometric exercise.European journal of applied physiology · 2022Article
- Isometric handgrip exercise impacts only on very short-term blood pressure variability, but not on short-term blood pressure variability in hypertensive individuals: A randomized controlled trial.Frontiers in physiology · 2022Article
- Feasibility study to assess the delivery of a novel isometric exercise intervention for people with stage 1 hypertension in the NHS: protocol for the IsoFIT-BP study including amendments to mitigate the risk of COVID-19.Pilot and feasibility studies · 2021Article
- Continuous cardiac autonomic and haemodynamic responses to isometric exercise in females.European journal of applied physiology · 2021Article
- Isometric Exercise Training: A Review of Hypothesized Mechanisms and Protocol Application in Persons with Hypertension.International journal of exercise science · 2021Review
- Isometric Handgrip as an Adjunct for Blood Pressure Control: a Primer for Clinicians.Current hypertension reports · 2017Review
- Acute cardiac functional and mechanical responses to isometric exercise in prehypertensive males.Physiological reports · 2017Article
- Exercise, the Brain, and Hypertension.Current hypertension reports · 2015Review
- 4-Second Exercise Test: Reference Values for Ages 18-81 Years.Arquivos brasileiros de cardiologia · 2015Article
- Effects of ovarian hormones and oral contraceptive pills on cardiac vagal withdrawal at the onset of dynamic exercise.PloS one · 2015Article
- Cardiac acceleration at the onset of exercise: a potential parameter for monitoring progress during physical training in sports and rehabilitation.Sports medicine (Auckland, N.Z.) · 2014Review
- Double-leg isometric exercise training in older men.Open access journal of sports medicine · 2013Article
- Isometric handgrip does not elicit cardiovascular overload or post-exercise hypotension in hypertensive older women.Clinical interventions in aging · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isometric handgrip (IHG) training (>6 weeks) has been shown to reduce resting arterial blood pressure (ABP) and improve cardiac autonomic modulation. However, the effects of a single bout of IHG on acute neurocardiac regulation remain unknown. The purpose of this study was to examine the effect of IHG exercise on nonlinear heart rate dynamics and cardiac vagal activity. Nonlinear dynamics were assessed by sample entropy, detrended fluctuation analysis (alpha(1)), and correlation dimension techniques. The 4-second exercise test was used to calculate the cardiac vagal index (CVI), an indirect measure of cardiac vagal activity. In a randomized crossover design, 18 older (70 +/- 5 years of age) subjects completed IHG exercise (four 2-min isometric contractions at 30% MVC) and a time-matched control condition. Following a single bout of bilateral IHG, there was a small reduction in systolic blood pressure (125 +/- 2 to 122 +/- 1 mmHg, P < 0.01), in addition to, a significant decrease in alpha(1) (1.42 +/- 0.12 to 1.22 +/- 0.10, P < 0.05), an increase in sample entropy (1.28 +/- 0.03 to 1.40 +/- 0.05, P < 0.001), and an increase in the CVI (1.24 +/- 0.03 to 1.29 +/- 0.03, P < 0.01). These results suggest improvements in acute cardiac autonomic modulation following a single bout of IHG. This may be mechanistically linked to the observed reductions in ABP seen in previous IHG training studies. Alternatively, these acute effects may have clinical applications and require further investigation.
Indexed as
Identifiers
19680681What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.