ArticlePloS one2009
Phosphodiesterase inhibition increases CREB phosphorylation and restores orientation selectivity in a model of fetal alcohol spectrum disorders.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Vinpocetine-An "Old" Drug with a New Face: Moving Toward a Better Understanding of Its Neuroprotective Mechanism of Action.Biomolecules · 2026Review
- Vinpocetine Ameliorates Neuronal Injury After Cold-Induced Traumatic Brain Injury in Mice.Molecular neurobiology · 2025Article
- Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development.Brain sciences · 2025Article
- Care, management, and use of ferrets in biomedical research.Laboratory animal research · 2024Review
- Binge-like Prenatal Ethanol Exposure Causes Impaired Cellular Differentiation in the Embryonic Forebrain and Synaptic and Behavioral Defects in Adult Mice.Brain sciences · 2022Article
- Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale.Journal of Alzheimer's disease reports · 2020Review
- Inhibition of PDE1-B by Vinpocetine Regulates Microglial Exosomes and Polarization Through Enhancing Autophagic Flux for Neuroprotection Against Ischemic Stroke.Frontiers in cell and developmental biology · 2020Article
- Updates of Recent Vinpocetine Research in Treating Cardiovascular Diseases.Journal of cellular immunology · 2020Article
- Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.Behavioral neuroscience · 2018Article
- Effects of developmental alcohol and valproic acid exposure on play behavior of ferrets.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Article
- Developmental alcohol exposure leads to a persistent change on astrocyte secretome.Journal of neurochemistry · 2016Article
- Phosphodiesterases as therapeutic targets for Alzheimer's disease.ACS chemical neuroscience · 2012Review
- Modulation of CREB in the dorsal lateral geniculate nucleus of dark-reared mice.Neural plasticity · 2012Article
- PDE1 isozymes, key regulators of pathological vascular remodeling.Current opinion in pharmacology · 2011Review
- From research to practice: an integrative framework for the development of interventions for children with fetal alcohol spectrum disorders.Neuropsychology review · 2011Review
- Fetal alcohol spectrum disorders and abnormal neuronal plasticity.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011Review
- Early valproic acid exposure alters functional organization in the primary visual cortex.Experimental neurology · 2011Article
- Therapeutic utility of phosphodiesterase type I inhibitors in neurological conditions.Frontiers in neuroscience · 2011Article
- Fetal alcohol spectrum disorders: experimental treatments and strategies for intervention.Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2011Review
- Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits.Alcoholism, clinical and experimental research · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFetal alcohol spectrum disorders (FASD) are the leading cause of mental retardation in the western world and children with FASD present altered somatosensory, auditory and visual processing. There is growing evidence that some of these sensory processing problems may be related to altered cortical maps caused by impaired developmental neuronal plasticity. METHODOLOGY/PRINCIPAL
findingsHere we show that the primary visual cortex of ferrets exposed to alcohol during the third trimester equivalent of human gestation have decreased CREB phosphorylation and poor orientation selectivity revealed by western blotting, optical imaging of intrinsic signals and single-unit extracellular recording techniques. Treating animals several days after the period of alcohol exposure with a phosphodiesterase type 1 inhibitor (Vinpocetine) increased CREB phosphorylation and restored orientation selectivity columns and neuronal orientation tuning. CONCLUSIONS/SIGNIFICANCE: These findings suggest that CREB function is important for the maturation of orientation selectivity and that plasticity enhancement by vinpocetine may play a role in the treatment of sensory problems in FASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.