ArticlePLoS genetics2009
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 557 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects
Non-Invasive Brain Stimulation and Delirium
Who cites it
557 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,085 citations in OpenAlex.
- Schizophrenia is associated with altered DNA methylation variance.Molecular psychiatry · 2025Pooled it
- A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes.Genome medicine · 2023Pooled it
- Disease classification for whole-blood DNA methylation: Meta-analysis, missing values imputation, and XAI.GigaScience · 2022Pooled it
- The Impact of Psychosocial Stress from Life Trauma and Racial Discrimination on Epigenetic Aging-A Systematic Review.Biological research for nursing · 2022Pooled it
- A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes.Nature communications · 2020Pooled it
- Article
- Chronological age estimation using CpG methylation signatures in Pakistani population.International journal of legal medicine · 2026Article
- Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026Review
- Epigenetic landscapes in human pancreatic islets reveal distinct drivers for adaptation to age and type 2 diabetes.Nature communications · 2026Article
- Variance-Guided Regression for Heteroscedastic Data With a Grouping-Based Extension for Nonlinear Prediction.Statistics in medicine · 2026Article
- DNA methylation and epigenomic profiling post-mortem of human remain analogs (Sus scrofa) in southern Ontario, Canada.Journal of forensic sciences · 2026Article
- An snRNA-seq aging clock for the fruit fly head sheds light on sex-biased aging.Scientific reports · 2026Article
- Epigenetic Signatures of Ageing in Asian Elephants Revealed by Reduced Representation Bisulphite Sequencing.Evolutionary applications · 2026Article
- Trauma exposure, PTSD, and methylation of the blood brain barrier claudin-5 gene.Psychoneuroendocrinology · 2026Article
- Evaluation of extraction methods for co-isolation of nucleic acid from human saliva for forensic body fluid identification.International journal of legal medicine · 2026Article
- Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions.Aging cell · 2026Article
- Pan-Epigenetic Age Prediction in Mammals.Aging cell · 2026Article
- Trauma Exposure, PTSD, and Methylation of the Blood Brain Barrier Claudin-5 Gene.medRxiv : the preprint server for health sciences · 2025Article
- FBLN2 promoter hypermethylation: a negative prognostic biomarker and anti-PD-1 response predictor in clear cell renal cell carcinoma via high-throughput CpG Island screening.Clinical epigenetics · 2025Article
- Aging by the clock and yet without a program.Nature aging · 2025Review
497 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human diseases, interindividual epigenetic variations in normal tissues due to aging, environmental factors, or innate susceptibility are poorly characterized. The plasticity, tissue-specific nature, and variability of gene expression are related to epigenomic states that vary across individuals. Thus, population-based investigations are needed to further our understanding of the fundamental dynamics of normal individual epigenomes. We analyzed 217 non-pathologic human tissues from 10 anatomic sites at 1,413 autosomal CpG loci associated with 773 genes to investigate tissue-specific differences in DNA methylation and to discern how aging and exposures contribute to normal variation in methylation. Methylation profile classes derived from unsupervised modeling were significantly associated with age (P<0.0001) and were significant predictors of tissue origin (P<0.0001). In solid tissues (n = 119) we found striking, highly significant CpG island-dependent correlations between age and methylation; loci in CpG islands gained methylation with age, loci not in CpG islands lost methylation with age (P<0.001), and this pattern was consistent across tissues and in an analysis of blood-derived DNA. Our data clearly demonstrate age- and exposure-related differences in tissue-specific methylation and significant age-associated methylation patterns which are CpG island context-dependent. This work provides novel insight into the role of aging and the environment in susceptibility to diseases such as cancer and critically informs the field of epigenomics by providing evidence of epigenetic dysregulation by age-related methylation alterations. Collectively we reveal key issues to consider both in the construction of reference and disease-related epigenomes and in the interpretation of potentially pathologically important alterations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.