ArticlePLoS computational biology2009
Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Turing-pattern model of scaffolding proteins that establish spatial asymmetry during the cell cycle ofiScience · 2023Article
- Modeling the temporal dynamics of master regulators and CtrA proteolysis in Caulobacter crescentus cell cycle.PLoS computational biology · 2022Article
- Computational modeling of unphosphorylated CtrA:iScience · 2021Article
- High-Temperature Live-Cell Imaging of Cytokinesis, Cell Motility, and Cell-Cell Interactions in the Thermoacidophilic CrenarchaeonFrontiers in microbiology · 2021Article
- Cell cycle control and environmental response by second messengers in Caulobacter crescentus.BMC bioinformatics · 2020Article
- Stochastic modeling and simulation of reaction-diffusion system with Hill function dynamics.BMC systems biology · 2017Article
- 3D time-varying simulations of CaInternational journal for numerical methods in biomedical engineering · 2017Article
- Dynamical Localization of DivL and PleC in the Asymmetric Division Cycle of Caulobacter crescentus: A Theoretical Investigation of Alternative Models.PLoS computational biology · 2015Article
- Dynamical modeling of the cell cycle and cell fate emergence in Caulobacter crescentus.PloS one · 2014Article
- Computational and genetic reduction of a cell cycle to its simplest, primordial components.PLoS biology · 2013Article
- Transcriptomic and phylogenetic analysis of a bacterial cell cycle reveals strong associations between gene co-expression and evolution.BMC genomics · 2013Article
- Spatial perturbation with synthetic protein scaffold reveals robustness of asymmetric cell division.Journal of biomedical science and engineering · 2013Article
- Potential role of a bistable histidine kinase switch in the asymmetric division cycle of Caulobacter crescentus.PLoS computational biology · 2013Article
- Phase resetting reveals network dynamics underlying a bacterial cell cycle.PLoS computational biology · 2012Article
- Computational modeling of signaling pathways mediating cell cycle checkpoint control and apoptotic responses to ionizing radiation-induced DNA damage.Dose-response : a publication of International Hormesis Society · 2012Article
- Mathematical modeling of fission yeast Schizosaccharomyces pombe cell cycle: exploring the role of multiple phosphatases.Systems and synthetic biology · 2011Article
- Temporal and spatial oscillations in bacteria.Nature reviews. Microbiology · 2011Review
- High-throughput, subpixel precision analysis of bacterial morphogenesis and intracellular spatio-temporal dynamics.Molecular microbiology · 2011Article
- Single-gene tuning of Caulobacter cell cycle period and noise, swarming motility, and surface adhesion.Molecular systems biology · 2010Article
- Modeling Dose-response at Low Dose: A Systems Biology Approach for Ionization Radiation.Dose-response : a publication of International Hormesis Society · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast into a quantitative computational model to investigate in a systematic fashion how these three proteins control the relevant genetic, biochemical and physiological properties of proliferating bacteria. Different controls for both swarmer and stalked cell cycles are represented in the mathematical scheme. The model is validated against observed phenotypes of wild-type cells and relevant mutants, and it predicts the phenotypes of novel mutants and of known mutants under novel experimental conditions. Because the cell cycle control proteins of Caulobacter are conserved across many species of alpha-proteobacteria, the model we are proposing here may be applicable to other genera of importance to agriculture and medicine (e.g., Rhizobium, Brucella).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.