ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2010
Comparison of methods for estimating glomerular filtration rate in critically ill patients with acute kidney injury.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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41 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Pooled it
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- Risk factors for acute kidney injury after nephron-sparing surgery in sporadic renal angiomyolipoma: a multicenter retrospective cohort study.BMC surgery · 2026Article
- Evaluation of 6-hour urine creatinine clearance as the kidney component in the SOFA score: An observational cohort study.Journal of intensive medicine · 2026Article
- Comparison of kinetic and standard formulas for estimating glomerular filtration rate in acute kidney injury: implications for antibiotic dosing, a prospective study.European journal of clinical pharmacology · 2025Observational
- Development and validation of a deep learning algorithm for the prediction of serum creatinine in critically ill patients.JAMIA open · 2024Article
- Effects of inpatient creatinine testing frequency on acute kidney injury identification and staging: a historical cohort study.International journal of clinical pharmacy · 2024Article
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- Diagnostic value and utility of commonly used biomarkers of cardiac and renal function in cardiorenal syndromes: a narrative review.Biochemia medica · 2023Review
- Creatinine Clearance in Acute Brain Injury: A Comparison of Methods.Neurocritical care · 2023Observational
- Effects of paricalcitol combined with hemodiafiltration on bone-metabolism-related indexes in patients with diabetic nephropathy and chronic renal failure.World journal of diabetes · 2023Article
- Meropenem pharmacokinetics in critically ill patients with or without burn treated with or without continuous veno-venous haemofiltration.British journal of clinical pharmacology · 2022Article
- Measured versus estimated creatinine clearance in critically ill patients with acute kidney injury: an observational study.Acute and critical care · 2022Article
- Creatinine correction to account for fluid overload in children with acute respiratory distress syndrome treated with extracorporeal membrane oxygenation: an initial exploratory report.Pediatric nephrology (Berlin, Germany) · 2022Observational
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- Population Pharmacokinetic Modeling and Simulations of Imipenem in Burn Patients With and Without Continuous Venovenous Hemofiltration in the Military Health System.Journal of clinical pharmacology · 2021Article
- The Glomerular Filtration Rate Estimators in the Pharmacokinetic Modelling in Acute Kidney Injury: An Observational Study.Antibiotics (Basel, Switzerland) · 2021Article
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Authors and funding
9 authors at 5 institutions in 1 country.
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Abstract
backgroundIn critically ill patients with acute kidney injury, estimates of kidney function are used to modify drug dosing, adjust nutritional therapy and provide dialytic support. However, estimating glomerular filtration rate is challenging due to fluctuations in kidney function, creatinine production and fluid balance. We hypothesized that commonly used glomerular filtration rate prediction equations overestimate kidney function in patients with acute kidney injury and that improved estimates could be obtained by methods incorporating changes in creatinine generation and fluid balance.
methodsWe analysed data from a multicentre observational study of acute kidney injury in critically ill patients. We identified 12 non-dialysed, non-oliguric patients with consecutive increases in creatinine for at least 3 and up to 7 days who had measurements of urinary creatinine clearance. Glomerular filtration rate was estimated by Cockcroft-Gault, Modification of Diet in Renal Disease, Jelliffe equation and Jelliffe equation with creatinine adjusted for fluid balance (Modified Jelliffe) and compared to measured urinary creatinine clearance.
resultsGlomerular filtration rate estimated by Jelliffe and Modification of Diet in Renal Disease equation correlated best with urinary creatinine clearances. Estimated glomerular filtration rate by Cockcroft-Gault, Modification of Diet in Renal Disease and Jelliffe overestimated urinary creatinine clearance was 80%, 33%, 10%, respectively, and Modified Jelliffe underestimated GFR by 2%.
conclusionIn patients with acute kidney injury, glomerular filtration rate estimating equations can be improved by incorporating data on creatinine generation and fluid balance. A better assessment of glomerular filtration rate in acute kidney injury could improve evaluation and management and guide interventions.
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