ArticleCerebral cortex (New York, N.Y. : 1991)2010
Uncertainty during anticipation modulates neural responses to aversion in human insula and amygdala.
Article in Cerebral cortex (New York, N.Y. : 1991), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula's role in the abstinence network.Addiction biology · 2021Pooled it
- Separate neural representations of prediction error valence and surprise: Evidence from an fMRI meta-analysis.Human brain mapping · 2018Pooled it
- The amygdala mediates the emotional modulation of threat-elicited skin conductance response.Emotion (Washington, D.C.) · 2014Trial
- Alcohol stress response dampening during imminent versus distal, uncertain threat.Journal of abnormal psychology · 2013Trial
- Alcohol stress response dampening: selective reduction of anxiety in the face of uncertain threat.Journal of psychopharmacology (Oxford, England) · 2012Trial
- Anterior insula integrates information about salience into perceptual decisions about pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Trial
- Sweet-taste liking is associated with preference for less risky and immediate rewards in economic decision-making.Frontiers in psychology · 2026Article
- Obesity and Insulin Resistance Alter Neural Processing of Unpleasant, but Not Pleasant, Visual Stimuli in Young Adults.Brain sciences · 2025Article
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- The effect of slow breathing in regulating anxiety.Scientific reports · 2025Article
- Learned helplessness and learned controllability: from neurobiology to cognitive, emotional and behavioral neurosciences.Frontiers in psychiatry · 2025Review
- Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025Review
- Investigating the effect of continuous and partial reinforcement in conceptual fear generalization.Scientific reports · 2024Article
- Clinical, behavioral, and electrophysiological profiles along a continuum of suicide risk: evidence from an implicit association task.Psychological medicine · 2024Article
- Neuropsychological analysis of anxiety and executive control of motor patterns in athletes and non-athletes.Frontiers in psychology · 2024Article
- Monoamine Oxidase: A Potential Link in Papez Circuit to Generalized Anxiety Disorders.CNS & neurological disorders drug targets · 2024Review
- Article
- Feeling uncertain despite knowing the risk: Patients with OCD (but not controls) experience known and unknown probabilistic decisions as similarly distressing and uncertain.Journal of obsessive-compulsive and related disorders · 2023Article
- Neural reactivity to threat impacts the association between bullying victimization and suicide risk in youth.Journal of psychiatric research · 2023Article
- Neural correlates of peer evaluation in irritable adolescents: Linking anticipation to receipt of social feedback.Biological psychology · 2023Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Uncertainty about potential negative future outcomes can cause stress and is a central feature of anxiety disorders. The stress and anxiety associated with uncertain situations may lead individuals to overestimate the frequency with which uncertain cues are followed by negative outcomes, an example of covariation bias. Using functional magnetic resonance imaging, we found that uncertainty-related expectations modulated neural responses to aversion. Insula and amygdala responses to aversive pictures were larger after an uncertain cue (that preceded aversive or neutral pictures) than a certain cue (that always preceded aversive pictures). Anticipatory anterior cingulate cortex (ACC) activity elicited by the cues was inversely associated with the insula and amygdala responses to aversive pictures following the cues. Nearly 75% of subjects overestimated the frequency of aversive pictures following uncertain cues, and ACC and insula activity predicted this uncertainty-related covariation bias. Findings provide the first evidence of the brain mechanisms of covariation bias and highlight the temporal dynamics of ACC, insula, and amygdala recruitment for processing aversion in the context of uncertainty.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.