ArticleJournal of vascular surgery2009
In vivo human lower extremity saphenous vein bypass grafts manifest flow mediated vasodilation.
Article in Journal of vascular surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
THE OMEGA-SPM-DOSE and OMEGA-SPM-PAD: Specialized Pro-Resolving Mediators in Patients With Peripheral Artery Disease
Arterial Imaging of Inflammation and Resolution After Endovascular Surgery
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).The Journal of surgical research · 2019Trial
- Trial
- Ebselen does not improve oxidative stress and vascular function in patients with diabetes: a randomized, crossover trial.American journal of physiology. Heart and circulatory physiology · 2016Trial
- Atazanavir improves cardiometabolic measures but not vascular function in patients with long-standing type 1 diabetes mellitus.Acta diabetologica · 2015Trial
- Vein graft preservation solutions, patency, and outcomes after coronary artery bypass graft surgery: follow-up from the PREVENT IV randomized clinical trial.JAMA surgery · 2014Trial
- n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial.Vascular medicine (London, England) · 2013Trial
- Contrary effects of the receptor tyrosine kinase inhibitor vandetanib on constitutive and flow-stimulated nitric oxide elaboration in humans.Hypertension (Dallas, Tex. : 1979) · 2011Trial
- Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia.Clinical and translational medicine · 2024Article
- Coronary atherosclerosis and chemotherapy: From bench to bedside.Frontiers in cardiovascular medicine · 2023Review
- Anticytomegalovirus CD4Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress.Clinical science (London, England : 1979) · 2020Article
- The effect of storage solutions on endothelial function and saphenous vein graft patency.Indian journal of thoracic and cardiovascular surgery · 2018Article
- Inflammation in Vein Graft Disease.Frontiers in cardiovascular medicine · 2018Review
- Vein graft failure: from pathophysiology to clinical outcomes.Nature reviews. Cardiology · 2016Review
- Measurement of brachial artery endothelial function using a standard blood pressure cuff.Physiological measurement · 2015Article
- Vein graft failure.Journal of vascular surgery · 2015Review
- Vein graft adaptation and fistula maturation in the arterial environment.The Journal of surgical research · 2014Review
- Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease.Journal of vascular surgery · 2013Article
- Small-diameter vascular tissue engineering.Nature reviews. Cardiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAs in arteries, venous endothelium modulates vessel homeostasis and tone. The effect of an arterialized environment on venous endothelial function remains poorly understood. In particular, regulation of saphenous vein graft (SVG) blood flow and lumen caliber remains undefined. We hypothesized that mature SVGs would exhibit endothelium-dependent, flow-mediated vasodilation (FMD). We further hypothesized that endothelium-derived nitric oxide (NO) was an important mediator.
methodsPatients with femoral to popliteal artery SVGs that had maintained primary patency and were at least 1 year from surgery were enrolled. High-resolution, B-mode ultrasound scans were used to measure vein graft diameter before and 1 minute after reactive hyperemia (RH) to determine FMD. RH was created through application of 220 mm Hg to the calf for 5 minutes with a sphygmomanometric cuff. After a 10-minute recovery period, nitroglycerin-mediated, endothelium-independent vasodilation was measured 3 minutes after administration of nitroglycerin 0.4 mg sublingually. Brachial artery FMD was determined by validated techniques. L-N(G)monomethyl arginine (L-NMMA; 1 mg/kg infusion over 10 minutes) was used in a subset of patients (n = 6) to competitively inhibit endothelial NO synthase.
resultsNineteen subjects were enrolled. The median age of the SVGs was 34.6 (21.0-49.7) months. SVG flow-mediated, endothelium-dependent vasodilation was measured at 5.28% +/- 3.1% mean change in lumen diameter (range, 1.99%-9.36%; P < .0001 for diameter change). Nitroglycerin-mediated vasodilation was 3.7% +/- 1.0%, (range, 16%-10.04%; P < .005). Intravenous administration of L-NMMA abolished SVG FMD (5.7 +/- 1.4% before L-NMMA vs 0.01 +/- 0.01% during L-NMMA infusion; P = .0088) and attenuated brachial artery FMD (7.54% +/- 1.0% vs 5.7 +/- 1.4; P = .05).
conclusionSVGs manifest flow-mediated, endothelium-dependent, and nitroglycerin-mediated endothelium-independent vasodilation. Vein graft endothelium-dependent FMD is likely mediated by NO. Further investigation will be required to determine the role of endothelial function in vein graft patency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.