ArticleBiochimica et biophysica acta2010
Proton transfer in catalysis and the role of proton shuttles in carbonic anhydrase.
Article in Biochimica et biophysica acta, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 88 citations in OpenAlex.
- Proton Transport as a Missing Design Variable in Immobilized Enzyme Catalysis.Chembiochem : a European journal of chemical biology · 2026Article
- Structural and functional characterization of a metagenomically derived γ-type carbonic anhydrase and its engineering into a hyperthermostable esterase.Protein science : a publication of the Protein Society · 2025Article
- Protein biochemistry and engineering drive the development of a carbonic anhydrase-based carbon dioxide sequestration strategy.The FEBS journal · 2025Article
- Rational engineering of a highly active and resilient α-carbonic anhydrase from the hydrothermal vent species Persephonella hydrogeniphila.The FEBS journal · 2025Article
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- Pepsin and Laryngeal and Hypopharyngeal Carcinomas.Clinical and experimental otorhinolaryngology · 2021Review
- αACS chemical neuroscience · 2021Article
- Human carbonic anhydrases and post-translational modifications: a hidden world possibly affecting protein properties and functions.Journal of enzyme inhibition and medicinal chemistry · 2020Review
- CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions.International journal of molecular sciences · 2020Article
- Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach.Journal of enzyme inhibition and medicinal chemistry · 2019Article
- Mechanism of Action of Non-Synonymous Single Nucleotide Variations Associated withMolecules (Basel, Switzerland) · 2019Article
- Cellular Small Molecules Contribute to Twister Ribozyme Catalysis.Journal of the American Chemical Society · 2018Article
- The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior.International journal of molecular sciences · 2018Article
- Protective Role of Carbonic Anhydrases III and VII in Cellular Defense Mechanisms upon Redox Unbalance.Oxidative medicine and cellular longevity · 2018Review
- Carbonic anhydrase 2-like in the giant clam,Physiological reports · 2017Article
- Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage.Journal of enzyme inhibition and medicinal chemistry · 2017Review
- Coupling Protein Dynamics with Proton Transport in Human Carbonic Anhydrase II.The journal of physical chemistry. B · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The undisputed role of His64 in proton transfer during catalysis by carbonic anhydrases in the alpha class has raised questions concerning the details of its mechanism. The highly conserved residues Tyr7, Asn62, and Asn67 in the active-site cavity function to fine tune the properties of proton transfer by human carbonic anhydrase II (HCA II). For example, hydrophobic residues at these positions favor an inward orientation of His64 and a low pK(a) for its imidazole side chain. It appears that the predominant manner in which this fine tuning is achieved in rate constants for proton transfer is through the difference in pK(a) between His64 and the zinc-bound solvent molecule. Other properties of the active-site cavity, such as inward and outward conformers of His64, appear associated with the change in DeltapK(a); however, there is no strong evidence to date that the inward and outward orientations of His64 are in themselves requirements for facile proton transfer in carbonic anhydrase.
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