ArticleStructure (London, England : 1993)2009
The CATH hierarchy revisited-structural divergence in domain superfamilies and the continuity of fold space.
Article in Structure (London, England : 1993), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Structural dynamics in the evolution of a bilobed protein scaffold.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- DALI and the persistence of protein shape.Protein science : a publication of the Protein Society · 2020Article
- The Urfold: Structural similarity just above the superfold level?Protein science : a publication of the Protein Society · 2019Article
- Protein structural motifs in prediction and design.Current opinion in structural biology · 2017Review
- Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance.Genome biology · 2017Article
- Development of a motif-based topology-independent structure comparison method to identify evolutionarily related folds.Proteins · 2016Article
- Diversity in protein domain superfamilies.Current opinion in genetics & development · 2015Review
- Review
- PDB-Explorer: a web-based interactive map of the protein data bank in shape space.BMC bioinformatics · 2015Article
- Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Chemical Society reviews · 2015Review
- CATH: comprehensive structural and functional annotations for genome sequences.Nucleic acids research · 2015Article
- Article
- Biophysical constraints on the evolution of tissue structure and function.The Journal of physiology · 2014Article
- Trends in structural coverage of the protein universe and the impact of the Protein Structure Initiative.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Rebelling for a reason: protein structural "outliers".PloS one · 2013Article
- Further evidence for the likely completeness of the library of solved single domain protein structures.The journal of physical chemistry. B · 2012Article
- Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis.Nucleic acids research · 2012Article
- The Proteome Folding Project: proteome-scale prediction of structure and function.Genome research · 2011Article
- Why not consider a spherical protein? Implications of backbone hydrogen bonding for protein structure and function.Physical chemistry chemical physics : PCCP · 2011Article
- Protein folds and protein folding.Protein engineering, design & selection : PEDS · 2011Review
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13 authors.
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Abstract
This paper explores the structural continuum in CATH and the extent to which superfamilies adopt distinct folds. Although most superfamilies are structurally conserved, in some of the most highly populated superfamilies (4% of all superfamilies) there is considerable structural divergence. While relatives share a similar fold in the evolutionary conserved core, diverse elaborations to this core can result in significant differences in the global structures. Applying similar protocols to examine the extent to which structural overlaps occur between different fold groups, it appears this effect is confined to just a few architectures and is largely due to small, recurring super-secondary motifs (e.g., alphabeta-motifs, alpha-hairpins). Although 24% of superfamilies overlap with superfamilies having different folds, only 14% of nonredundant structures in CATH are involved in overlaps. Nevertheless, the existence of these overlaps suggests that, in some regions of structure space, the fold universe should be seen as more continuous.
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