ArticleNeuron2009
Linking genetically defined neurons to behavior through a broadly applicable silencing allele.
Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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Who cites it
96 citing papers in PubMed.
- Behavioral impact of chemogenetic manipulations of 5-HT DRN neurons in transgenic Tph2-iCre rats.Psychopharmacology · 2026Article
- Specialized outputs and behavioral contributions of Purkinje cell subtypes.bioRxiv : the preprint server for biology · 2026Article
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- Pre-Sensory Spontaneous Activity Accelerates Coordinated Maturation of Synaptic Partners and Drives Transition to the Mature Physiological Phenotype.bioRxiv : the preprint server for biology · 2025Article
- The neural pathway from the superior subpart of the medial habenula to the interpeduncular nucleus suppresses anxiety.Molecular psychiatry · 2025Article
- A top-down insular cortex circuit crucial for non-nociceptive fear learning.Science advances · 2025Article
- Mechanisms of neuromodulatory volume transmission.Molecular psychiatry · 2024Review
- Ablation of TrkB from Enkephalinergic Precursor-Derived Cerebellar Granule Cells Generates Ataxia.Biology · 2024Article
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- Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity.Research square · 2024Article
- Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity.bioRxiv : the preprint server for biology · 2024Article
- Parabrachial Calca neurons drive nociplasticity.Cell reports · 2024Article
- Diverse roles of pontine NPS-expressing neurons in sleep regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Nerve injury disrupts temporal processing in the spinal cord dorsal horn through alterations in PVCell reports · 2024Article
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- Advanced neurobiological tools to interrogate metabolism.Nature reviews. Endocrinology · 2023Review
- A brain circuit and neuronal mechanism for decoding and adapting to change in daylength.bioRxiv : the preprint server for biology · 2023Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Tools for suppressing synaptic transmission gain power when able to target highly selective neuron subtypes, thereby sharpening attainable links between neuron type, behavior, and disease; and when able to silence most any neuron subtype, thereby offering broad applicability. Here, we present such a tool, RC::PFtox, that harnesses breadth in scope along with high cell-type selection via combinatorial gene expression to deliver tetanus toxin light chain (tox), an inhibitor of vesicular neurotransmission. When applied in mice, we observed cell-type-specific disruption of vesicle exocytosis accompanied by loss of excitatory postsynaptic currents and commensurately perturbed behaviors. Among various test populations, we applied RC::PFtox to silence serotonergic neurons, en masse or a subset defined combinatorially. Of the behavioral phenotypes observed upon en masse serotonergic silencing, only one mapped to the combinatorially defined subset. These findings provide evidence for separability by genetic lineage of serotonin-modulated behaviors; collectively, these findings demonstrate broad utility of RC::PFtox for dissecting neuron functions.
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Registered trials
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