Evidence map›Paper›PMID 19679068›Full record

ArticleNeuron2009

The pre/post LTP debate.

John E Lisman

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. How to erase memory traces of pain and fear.Trends in neurosciences · 2013
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012
    Article
  11. A frontier in the understanding of synaptic plasticity: solving the structure of the postsynaptic density.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012
    Review
  12. Imaging synaptic plasticity.Molecular brain · 2011
    Review
  13. Article
  14. Article
  15. Article
  16. GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

John E LismanDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA. lisman@brandeis.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pre/post debate involves the question of whether long-term potentiation (LTP) is mediated by enhancement of release, enhancement of postsynaptic receptors, or both. Recent papers have presented evidence for purely postsynaptic or purely presynaptic changes, and a paper by Ahmed and Siegelbam (in this issue of Neuron) suggests a mechanism by which release is enhanced. This debate is increasingly constrained by technical advances that allow central synapses to be studied with increasing precision. A possible of way of reconciling conflicting evidence is suggested.

Indexed as

AnimalsLong-Term PotentiationMiceModels, NeurologicalSynapsesSynaptic Transmission

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.