ArticleCritical care (London, England)2009
Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CSP #530 - Intensive vs. Conventional Renal Support in Acute Renal Failure
A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients With Acute Kidney Injury Requiring Continuous Kidney Replacement Therapy
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Timing of kidney replacement therapy initiation for acute kidney injury.The Cochrane database of systematic reviews · 2022Pooled it
- Non-pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy.The Cochrane database of systematic reviews · 2021Pooled it
- Timing of renal replacement therapy initiation for acute kidney injury.The Cochrane database of systematic reviews · 2018Pooled it
- Intensity of continuous renal replacement therapy for acute kidney injury.The Cochrane database of systematic reviews · 2016Pooled it
- Peritoneal dialysis does not adversely affect kidney function recovery after congenital heart surgery.The International journal of artificial organs · 2014Trial
- Care of the chronic dialysis patient in the intensive care unit: a state-of-the-art review.Critical care science · 2025Review
- Economic Analysis of Renal Replacement Therapy Modality in Acute Kidney Injury Patients With Fluid Overload.Critical care explorations · 2023Article
- Continuous Venovenous Hemofiltration is Associated with Improved Survival in Burn Patients with Shock: A Subset Analysis of a Multicenter Observational Study.Blood purification · 2021Observational
- Effect of adult COVID-19 surge on the provision of kidney replacement therapy in children.Pediatric nephrology (Berlin, Germany) · 2020Article
- Does Your Program Know Its AKI and CRRT Epidemiology? The Case for a Dashboard.Frontiers in pediatrics · 2020Review
- Review
- Renal Replacement Therapy in Severe Burns: A Multicenter Observational Study.Journal of burn care & research : official publication of the American Burn Association · 2018Observational
- Effect of Frequent Dialysis on Renal Recovery: Results From the Acute Renal Failure Trial Network Study.Kidney international reports · 2018Article
- Promoting Kidney Function Recovery in Patients with AKI Requiring RRT.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Economics of dialysis dependence following renal replacement therapy for critically ill acute kidney injury patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Article
- Plasma inflammatory and apoptosis markers are associated with dialysis dependence and death among critically ill patients receiving renal replacement therapy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Observational
- Dosing of renal replacement therapy in acute kidney injury.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2012Review
- Model to predict mortality in critically ill adults with acute kidney injury.Clinical journal of the American Society of Nephrology : CJASN · 2011Article
- Clinical review: Optimal dose of continuous renal replacement therapy in acute kidney injury.Critical care (London, England) · 2011Review
- Update of acute kidney injury: intensive care nephrology.Hippokratia · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Determination of the optimal dose of renal replacement therapy in critically ill patients with acute kidney injury has been controversial. Questions have recently been raised regarding the design and execution of the US Department of Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network (ATN) Study, which demonstrated no improvement in 60-day all-cause mortality with more intensive management of renal replacement therapy. In the present article we present our rationale for these aspects of the design and conduct of the study, including our use of both intermittent and continuous modalities of renal support, our approach to initiation of study therapy and the volume management during study therapy. In addition, the article presents data on hypotension during therapy and recovery of kidney function in the perspective of other studies of renal support in acute kidney injury. Finally, we address the implications of the ATN Study results for clinical practice from the perspective of the study investigators.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.