Trial reportAlimentary pharmacology & therapeutics2009
Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers.
Trial report in Alimentary pharmacology & therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 89 citations in OpenAlex.
- Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.Clinical pharmacology and therapeutics · 2025Trial
- Randomized controlled trial: Standard versus supplemental bowel preparation in patients with Bristol stool form 1 and 2.PloS one · 2017Trial
- Bowel cleansing before CT colonography: comparison between two minimal-preparation regimens.European radiology · 2015Trial
- Diagnosis and treatment of slow-transit constipation.BMC gastroenterology · 2026Review
- Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (Antioxidants (Basel, Switzerland) · 2024Article
- Comparing silver and gold nanoislands' surface plasmon resonance for bisacodyl and its metabolite quantification in human plasma.BMC chemistry · 2024Article
- Results of medical treatment with psyllium, lactobacillus, and tryptophan (Plurilac® Trio) in obstructive defecation syndrome.Frontiers in surgery · 2024Article
- Bisacodyl Limits Chikungunya Virus ReplicationAntimicrobial agents and chemotherapy · 2022Article
- Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation.Neurogastroenterology and motility · 2021Review
- The unmet needs for identifying the ideal bowel preparation.JGH open : an open access journal of gastroenterology and hepatology · 2021Review
- Bowel preparation in diabetic patients undergoing colonoscopy.Annals of gastroenterology · 2021Review
- Review
- Chronic Constipation.Mayo Clinic proceedings · 2019Review
- Usefulness of Bisacodyl Testing on Therapeutic Outcomes in Refractory Constipation.Digestive diseases and sciences · 2018Article
- Expert consensus on the assessment and treatment of chronic constipation in the elderly.Aging medicine (Milton (N.S.W)) · 2018Article
- New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond.World journal of gastroenterology · 2017Review
- Emerging treatments in Neurogastroenterology: relamorelin: a novel gastrocolokinetic synthetic ghrelin agonist.Neurogastroenterology and motility · 2015Review
- Common GI Drug Interactions in the Elderly.Current treatment options in gastroenterology · 2014Article
- Gastrointestinal motility disorders in children.Gastroenterology & hepatology · 2014Article
- American Gastroenterological Association technical review on constipation.Gastroenterology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe mechanism of action of bisacodyl in the unprepared human colon remains unclear.
aimTo evaluate the effect of oral bisacodyl on the overall and regional colonic transit in humans.
methodsIn a double-blind, randomized, placebo-controlled study of 25 healthy participants, effects of oral bisacodyl (5 mg p.o. per day) and placebo on colonic transit were compared. A validated scintigraphy method was used to measure colonic transit. The primary transit endpoints, ascending colon emptying t(1/2) and geometric centre of colon isotope at 24 h (overall transit), were compared (Wilcoxon rank sum test).
resultsThere were significant treatment effects on ascending colon t(1/2), with the bisacodyl group demonstrating accelerated emptying [median 6.5 h, interquartile range 5.0-8.0 h] relative to the placebo group [11.0 h (7.0-17.1); P = 0.03]. Numerical differences in colonic geometric centre 24 h [bisacodyl median 3.0 (2.2-3.8), placebo 4.0 (3.1-4.6)] were not significant (P = 0.19). There were no significant differences observed in geometric centre 4 h.
conclusionOral 5 mg bisacodyl accelerates ascending colon in the unprepared colon in healthy adults; this action may contribute to the drug's efficacy in constipation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.