Evidence map›Paper›PMID 19678613›Full record

ArticleOrganic letters2009

Small molecule ligands for bulged RNA secondary structures.

S Todd Meyer, Paul J Hergenrother

Abstract read
In one paragraph

Article in Organic letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Structure-activity studies of RNA-binding oxazolidinone derivatives.Bioorganic & medicinal chemistry letters · 2011
    Article
  9. Article
  10. Article
  11. Frameworks for targeting RNA with small molecules.The Journal of biological chemistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

S Todd MeyerDepartment of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, USA.
Paul J Hergenrother

Funding

Targeting CUG Expansions for the Treatment of Myotonic DystrophyR01AR058361 · NIAMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL, ZIMMERMAN, STEVEN C. · 2009 to 2013
$1.7M
NIAMS NIH HHS R01 AR058361NIAMS NIH HHS R01AR058361
6 · The paper itself

Abstract

A class of wedge-shaped small molecules has been designed, synthesized, and shown to bind bulged RNA secondary structures. These minimally cationic ligands exhibit good affinity and selectivity for certain RNA bulges as demonstrated in a fluorescent intercalator displacement assay.

Indexed as

G-QuadruplexesIntercalating AgentsModels, ChemicalMolecular Sequence DataNucleic Acid ConformationRNAStructure-Activity RelationshipIntercalating AgentsRNA

Identifiers

PMID19678613
PMCPMC4975938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.