ArticleProceedings of the National Academy of Sciences of the United States of America1990
Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 121 citations in OpenAlex.
- HER2 inhibition increases non-muscle myosin IIA to promote tumorigenesis in HER2+ breast cancers.PloS one · 2023Article
- WAVE2 Protein Complex Coupled to Membrane and Microtubules.Journal of oncology · 2012Article
- Glomerular diseases: genetic causes and future therapeutics.Nature reviews. Nephrology · 2010Review
- GADD34 suppresses wound healing by upregulating expression of myosin IIA.Transgenic research · 2010Article
- Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading.PloS one · 2010Article
- Regulated proteolysis of nonmuscle myosin IIA stimulates osteoclast fusion.The Journal of biological chemistry · 2009Article
- Nonmuscle myosin heavy chain-B expression in balloon-dilated and stented arteries: a study in the atherosclerotic Yucatan micropig.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2005Article
- Article
- Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9.American journal of human genetics · 2000Article
- Conditional expression of a truncated fragment of nonmuscle myosin II-A alters cell shape but not cytokinesis in HeLa cells.Molecular biology of the cell · 2000Article
- ARG1 (altered response to gravity) encodes a DnaJ-like protein that potentially interacts with the cytoskeleton.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Differential expression and functions of cortical myosin IIA and IIB isotypes during meiotic maturation, fertilization, and mitosis in mouse oocytes and embryos.Molecular biology of the cell · 1998Article
- Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation.Molecular and cellular biology · 1998Article
- Nonmuscle myosin II-B is required for normal development of the mouse heart.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Alternative poly(A) site selection in complex transcription units: means to an end?Nucleic acids research · 1997Review
- Xenopus nonmuscle myosin heavy chain isoforms have different subcellular localizations and enzymatic activities.The Journal of cell biology · 1996Article
- Cloning of the cDNA encoding rat myosin heavy chain-A and evidence for the absence of myosin heavy chain-B in cultured rat mast (RBL-2H3) cells.Journal of muscle research and cell motility · 1996Article
- Characterization of the nonmuscle myosin heavy chain IIB promoter: regulation by E2F.Gene expression · 1996Article
- Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies.Journal of muscle research and cell motility · 1995Article
- Non-muscle myosin II heavy chain has a cryptic cell-adhesion domain.The Biochemical journal · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Myosin is a ubiquitous eukaryotic contractile protein that generates the force responsible for such diverse cellular movements as muscle contraction and cytokinesis. Although there have been numerous studies of sarcomeric myosin heavy chain (MHC) genes, no molecular clones have been reported that encode mammalian nonmuscle MHC. This study presents the molecular genetic characterization of a human nonmuscle MHC that is expressed in fibroblasts, endothelial cells, and macrophages. Human nonmuscle MHC amino acids are weakly homologous (33%) to sarcomeric MHC but are approximately 72% identical to smooth muscle MHC. In contrast to vertebrate sarcomeric MHCs, which generate diversity through the expression of members of a multigene family, an alternative polyadenylylation site is used in the nonmuscle MHC gene to generate multiple transcripts that encode the same protein. We have mapped this gene to chromosome 22. It is thus unlinked to either of the sarcomeric MHC gene clusters on human chromosomes 14 and 17.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.