ArticleThe Journal of cell biology1990
Redistribution of synaptophysin and synapsin I during alpha-latrotoxin-induced release of neurotransmitter at the neuromuscular junction.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 122 citations in OpenAlex.
- The Structural Basis of Long-Term Potentiation in Hippocampal Synapses, Revealed by Electron Microscopy Imaging of Lanthanum-Induced Synaptic Vesicle Recycling.Frontiers in cellular neuroscience · 2022Article
- Synaptic vesicle recycling: steps and principles.The EMBO journal · 2014Review
- Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.Frontiers in cellular neuroscience · 2014Article
- The role of synapsins in neuronal development.Cellular and molecular life sciences : CMLS · 2010Review
- Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesicles.Molecular biology of the cell · 2003Article
- Regulated delivery of AMPA receptor subunits to the presynaptic membrane.The EMBO journal · 2003Article
- Fluorescence resonance energy transfer detection of synaptophysin I and vesicle-associated membrane protein 2 interactions during exocytosis from single live synapses.Molecular biology of the cell · 2002Article
- Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Botulinum neurotoxin A blocks synaptic vesicle exocytosis but not endocytosis at the nerve terminal.The Journal of cell biology · 1999Article
- The frog neuromuscular junction revisited after quick-freezing-freeze-drying: ultrastructure, immunogold labelling and high resolution calcium mapping.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1999Article
- Synapsins as regulators of neurotransmitter release.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1999Review
- Visualization of the dynamics of synaptic vesicle and plasma membrane proteins in living axons.The Journal of cell biology · 1998Article
- Synaptic vesicles have two distinct recycling pathways.The Journal of cell biology · 1996Article
- A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I alpha associates with synaptic vesicles and phosphorylates a subset of vesicle proteins.The Journal of cell biology · 1995Article
- The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling.The Journal of cell biology · 1995Article
- Targeting of the "insulin-responsive" glucose transporter (GLUT4) to the regulated secretory pathway in PC12 cells.The Journal of cell biology · 1993Article
- Mechanisms in the regulation of neurotransmitter release from brain nerve terminals: current hypotheses.Neurochemical research · 1993Review
- Specific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle.The Journal of cell biology · 1992Article
- Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons.The Journal of cell biology · 1992Article
- Purification of an Arg-Gly-Asp selective matrix receptor from brain synaptic plasma membranes.The Biochemical journal · 1992Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The distribution of two synaptic vesicle-specific phosphoproteins, synaptophysin and synapsin I, during intense quantal secretion was studied by applying an immunogold labeling technique to ultrathin frozen sections. In nerve-muscle preparations treated for 1 h with a low dose of alpha-latrotoxin in the absence of extracellular Ca2+ (a condition under which nerve terminals are depleted of both quanta of neurotransmitter and synaptic vesicles), the immunolabeling for both proteins was distributed along the axolemma. These findings indicate that, in the presence of a block of endocytosis, exocytosis leads to the permanent incorporation of the synaptic vesicle membrane into the axolemma and suggest that, under this condition, at least some of the synapsin I molecules remain associated with the vesicle membrane after fusion. When the same dose of alpha-latrotoxin was applied in the presence of extracellular Ca2+, the immunoreactivity patterns resembled those obtained in resting preparations: immunogold particles were selectively associated with the membrane of synaptic vesicles, whereas the axolemma was virtually unlabeled. Under this condition an active recycling of both quanta of neurotransmitter and vesicles operates. These findings indicate that the retrieval of components of the synaptic vesicle membrane is an efficient process that does not involve extensive intermixing between molecular components of the vesicle and plasma membrane, and show that synaptic vesicles that are rapidly recycling still have the bulk of synapsin I associated with their membrane.
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