ArticlePloS one2009
Emergence of community-associated methicillin-resistant Staphylococcus aureus associated with pediatric infection in Cambodia.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Methicillin resistantTropical doctor · 2023Article
- Diversity and Dissemination of Methicillin-ResistantTropical medicine and infectious disease · 2022Review
- Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.Clinical microbiology reviews · 2018Review
- Molecular Epidemiology ofThe American journal of tropical medicine and hygiene · 2017Article
- Characterization of community-associated Staphylococcus aureus from skin and soft-tissue infections: a multicenter study in China.Emerging microbes & infections · 2016Article
- Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly.New microbes and new infections · 2016Article
- Comparison of community-onset Staphylococcus argenteus and Staphylococcus aureus sepsis in Thailand: a prospective multicentre observational study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2016Observational
- Drug resistance in bacteria isolated from patients presenting with wounds at a non-profit Surgical Center in Phnom Penh, Cambodia from 2011-2013.Tropical diseases, travel medicine and vaccines · 2015Article
- Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia.Tropical medicine & international health : TM & IH · 2015Article
- Ophthalmic infections in children presenting to Angkor Hospital for Children, Siem Reap, Cambodia.BMC research notes · 2014Article
- Epidemiology of bacteremia in young hospitalized infants in Vientiane, Laos, 2000-2011.Journal of tropical pediatrics · 2014Article
- Community-associated methicillin-resistant Staphylococcus aureus case studies.Methods in molecular biology (Clifton, N.J.) · 2014Review
- A prospective study of the causes of febrile illness requiring hospitalization in children in Cambodia.PloS one · 2013Article
- Subpopulations of Staphylococcus aureus clonal complex 121 are associated with distinct clinical entities.PloS one · 2013Article
- Bloodstream infection among adults in Phnom Penh, Cambodia: key pathogens and resistance patterns.PloS one · 2013Article
- Article
- Antimicrobial susceptibility of bacterial isolates from community acquired infections in Sub-Saharan Africa and Asian low and middle income countries.Tropical medicine & international health : TM & IH · 2011Review
- Management of adolescents and adults with febrile illness in resource limited areas.BMJ (Clinical research ed.) · 2011Review
- A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus.PloS one · 2011Article
- Nasal carriage of Staphylococcus aureus in healthy humans with different levels of contact with animals in Tunisia: genetic lineages, methicillin resistance, and virulence factors.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundThe incidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection is rising in the developed world but appears to be rare in developing countries. One explanation for this difference is that resource poor countries lack the diagnostic microbiology facilities necessary to detect the presence of CA-MRSA carriage and infection. METHODOLOGY AND PRINCIPAL
findingsWe developed diagnostic microbiology capabilities at the Angkor Hospital for Children, Siem Reap, western Cambodia in January 2006 and in the same month identified a child with severe community-acquired impetigo caused by CA-MRSA. A study was undertaken to identify and describe additional cases presenting between January 2006 and December 2007. Bacterial isolates underwent molecular characterization using multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec) typing, and PCR for the presence of the genes encoding Panton-Valentine Leukocidin (PVL). Seventeen children were identified with CA-MRSA infection, of which 11 had skin and soft tissue infection and 6 had invasive disease. The majority of cases were unrelated in time or place. Molecular characterization identified two independent MRSA clones; fifteen isolates were sequence type (ST) 834, SCCmec type IV, PVL gene-negative, and two isolates were ST 121, SCCmec type V, PVL gene-positive.
conclusionsThis represents the first ever report of MRSA in Cambodia, spread of which would pose a significant threat to public health. The finding that cases were mostly unrelated in time or place suggests that these were sporadic infections in persons who were CA-MRSA carriers or contacts of carriers, rather than arising in the context of an outbreak.
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