Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2009
Impairments of probabilistic response reversal and passive avoidance following catecholamine depletion.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Age moderates the effect of acute dopamine depletion on passive avoidance learning.Pharmacology, biochemistry, and behavior · 2015Trial
- Nicotine withdrawal modulates frontal brain function during an affective Stroop task.Psychopharmacology · 2012Trial
- From Neural Circuits to Behavior: Examining the Central Role of Anhedonia in Major Depression.Advances in experimental medicine and biology · 2026Review
- Behavioral Response to Catecholamine Depletion in Individuals With Schizophrenia and Healthy Volunteers.Schizophrenia bulletin open · 2023Article
- Presentation and Neurobiology of Anhedonia in Mood Disorders: Commonalities and Distinctions.Current psychiatry reports · 2018Review
- Assessing anhedonia in depression: Potentials and pitfalls.Neuroscience and biobehavioral reviews · 2016Review
- Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies.Neuroscience and biobehavioral reviews · 2015Review
- Dopamine depletion attenuates some behavioral abnormalities in a hyperdopaminergic mouse model of bipolar disorder.Journal of affective disorders · 2014Article
- To treat a psychopath.Theoretical medicine and bioethics · 2014Article
- Dopaminergic control of cognitive flexibility in humans and animals.Frontiers in neuroscience · 2013Review
- The neurobiology of psychopathic traits in youths.Nature reviews. Neuroscience · 2013Review
- Measuring extrastriatal dopamine release during a reward learning task.Human brain mapping · 2013Article
- Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognition.Psychiatry research · 2013Article
- Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder.The American journal of psychiatry · 2012Article
- Neurocognitive correlates of the effects of yoga meditation practice on emotion and cognition: a pilot study.Frontiers in integrative neuroscience · 2012Article
- Neuromodulation of reward-based learning and decision making in human aging.Annals of the New York Academy of Sciences · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Catecholamines, particularly dopamine, have been implicated in various aspects of the reward function including the ability to learn through reinforcement and to modify flexibly responses to changing reinforcement contingencies. We examined the impact of catecholamine depletion (CD) achieved by oral administration of alpha-methyl-paratyrosine (AMPT) on probabilistic reversal learning and passive avoidance (PA) in 15 female subjects with major depressive disorder in full remission (RMDD) and 12 healthy female controls. The CD did not affect significantly the acquisition phase of the reversal learning task. However, CD selectively impaired reversal of the 80-20 contingency pair. In the PA learning task, CD was associated with reduced responding toward rewarding stimuli, although the RMDD and control subjects did not differ regarding these CD-induced changes in reward processing. Interestingly, the performance decrement produced by AMPT on both of these tasks was associated with the level of decreased metabolism in the perigenual anterior cingulate cortex. In an additional examination using the affective Stroop task we found evidence for impaired executive attention as a trait abnormality in MDD. In conclusion, this study showed specific effects of CD on the processing of reward-related stimuli in humans and confirms earlier investigations that show impairments of executive attention as a neuropsychological trait in affective illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.