ArticleJournal of neurophysiology2009
SK channels gate information processing in vivo by regulating an intrinsic bursting mechanism seen in vitro.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 57 citations in OpenAlex.
- In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.PLoS computational biology · 2025Article
- Burst firing optimizes invariant coding of natural communication signals by electrosensory neural populations.iScience · 2025Article
- Electrosensory midbrain neurons optimally decode ascending input during object localization.The Journal of physiology · 2025Article
- Nonresponsive Neurons Improve Population Coding of Object Location.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Descending pathways increase sensory neural response heterogeneity to facilitate decoding and behavior.iScience · 2023Article
- Coding of object location by heterogeneous neural populations with spatially dependent correlations in weakly electric fish.PLoS computational biology · 2023Article
- Population Coding of Natural Electrosensory Stimuli by Midbrain Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Intrinsic burst-firing in lamina I spinoparabrachial neurons during adolescence.Neuroscience letters · 2021Article
- Positive Modulation of SK Channel Impedes Neuron-Specific Cytoskeletal Organization and Maturation.Developmental neuroscience · 2020Article
- Neural Synchrony Gives Rise to Amplitude- and Duration-Invariant Encoding Consistent With Perception of Natural Communication Stimuli.Frontiers in neuroscience · 2020Article
- Serotonergic Modulation of Sensory Neuron Activity and Behavior inFrontiers in integrative neuroscience · 2020Article
- Descending pathways mediate adaptive optimized coding of natural stimuli in weakly electric fish.Science advances · 2019Article
- SK Channel Modulates Synaptic Plasticity by Tuning CaMKIIα/β Dynamics.Frontiers in synaptic neuroscience · 2019Article
- Article
- Descending pathways generate perception of and neural responses to weak sensory input.PLoS biology · 2018Article
- Differential receptive field organizations give rise to nearly identical neural correlations across three parallel sensory maps in weakly electric fish.PLoS computational biology · 2017Article
- Article
- Electrosensory neural responses to natural electro-communication stimuli are distributed along a continuum.PloS one · 2017Article
- Electrosensory processing in Apteronotus albifrons: implications for general and specific neural coding strategies across wave-type weakly electric fish species.Journal of neurophysiology · 2016Article
- Optimized Parallel Coding of Second-Order Stimulus Features by Heterogeneous Neural Populations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Understanding the mechanistic substrates of neural computations that lead to behavior remains a fundamental problem in neuroscience. In particular, the contributions of intrinsic neural properties such as burst firing and dendritic morphology to the processing of behaviorally relevant sensory input have received much interest recently. Pyramidal cells within the electrosensory lateral line lobe of weakly electric fish display an intrinsic bursting mechanism that relies on somato-dendritic interactions when recorded in vitro: backpropagating somatic action potentials trigger dendritic action potentials that lead to a depolarizing afterpotential (DAP) at the soma. We recorded intracellularly from these neurons in vivo and found firing patterns that were quite different from those seen in vitro: we found no evidence for DAPs as each somatic action potential was followed by a pronounced afterhyperpolarization (AHP). Calcium chelators injected in vivo reduced the AHP, thereby unmasking the DAP and inducing in vitro-like bursting in pyramidal cells. These bursting dynamics significantly reduced the cell's ability to encode the detailed time course of sensory input. We performed additional in vivo pharmacological manipulations and mathematical modeling to show that calcium influx through N-methyl-d-aspartate (NMDA) receptors activate dendritic small conductance (SK) calcium-activated potassium channels, which causes an AHP that counteracts the DAP and leads to early termination of the burst. Our results show that ion channels located in dendrites can have a profound influence on the processing of sensory input by neurons in vivo through the modulation of an intrinsic bursting mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.