ArticleJournal of neurophysiology2009
Enhanced calcium buffering in F344 rat cholinergic basal forebrain neurons is associated with age-related cognitive impairment.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Glial Cells Response in Stroke.Cellular and molecular neurobiology · 2023Review
- Late-Onset, Short-Term Intermittent Fasting Reverses Age-Related Changes in Calcium Buffering and Inhibitory Synaptic Transmission in Mouse Basal Forebrain Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Amitriptyline Decreases GABAergic Transmission in Basal Forebrain Neurons Using an Optogenetic Model of Aging.Frontiers in aging neuroscience · 2021Article
- CaCells · 2020Review
- Verapamil and Alzheimer's Disease: Past, Present, and Future.Frontiers in pharmacology · 2020Review
- Electrophysiological and Imaging Calcium Biomarkers of Aging in Male and Female 5×FAD Mice.Journal of Alzheimer's disease : JAD · 2020Article
- 20 Years of Secretagogin: Exocytosis and Beyond.Frontiers in molecular neuroscience · 2019Article
- Expression of a Constitutively Active Human Insulin Receptor in Hippocampal Neurons Does Not Alter VGCC Currents.Neurochemical research · 2019Article
- Calcium's role as nuanced modulator of cellular physiology in the brain.Biochemical and biophysical research communications · 2017Review
- White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke.Experimental neurology · 2015Article
- Effect of a water-maze procedure on the redox mechanisms in brain parts of aged rats.Frontiers in aging neuroscience · 2015Article
- FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?European journal of pharmacology · 2014Review
- Characterization of age-related changes in synaptic transmission onto F344 rat basal forebrain cholinergic neurons using a reduced synaptic preparation.Journal of neurophysiology · 2014Article
- Hippocampal calcium dysregulation at the nexus of diabetes and brain aging.European journal of pharmacology · 2013Review
- Distinct manifestations of executive dysfunction in aged rats.Neurobiology of aging · 2013Article
- Distribution of secretagogin-containing neurons in the basal forebrain of mice, with special reference to the cholinergic corticopetal system.Brain research bulletin · 2013Article
- Age-related changes in rostral basal forebrain cholinergic and GABAergic projection neurons: relationship with spatial impairment.Neurobiology of aging · 2013Article
- Adult mouse basal forebrain harbors two distinct cholinergic populations defined by their electrophysiology.Frontiers in behavioral neuroscience · 2012Article
- Risk, reward, and decision-making in a rodent model of cognitive aging.Frontiers in neuroscience · 2011Article
- Learning and aging related changes in intrinsic neuronal excitability.Frontiers in aging neuroscience · 2010Article
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6 authors.
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Abstract
Alterations in neuronal Ca(2+) homeostasis are important determinants of age-related cognitive impairment. We examined the Ca(2+) influx, buffering, and electrophysiology of basal forebrain neurons in adult, middle-aged, and aged male F344 behaviorally assessed rats. Middle-aged and aged rats were characterized as cognitively impaired or unimpaired by water maze performance relative to young cohorts. Patch-clamp experiments were conducted on neurons acutely dissociated from medial septum/nucleus of the diagonal band with post hoc identification of phenotypic marker mRNA using single-cell RT-PCR. We measured whole cell calcium and barium currents and dissected these currents using pharmacological agents. We combined Ca(2+) current recording with Ca(2+)-sensitive ratiometric microfluorimetry to measure Ca(2+) buffering. Additionally, we sought changes in neuronal firing properties using current-clamp recording. There were no age- or cognition-related changes in the amplitudes or fractional compositions of the whole cell Ca(2+) channel currents. However, Ca(2+) buffering was significantly enhanced in cholinergic neurons from aged cognitively impaired rats. Moreover, increased Ca(2+) buffering was present in middle-aged rats that were not cognitively impaired. Firing properties were largely unchanged with age or cognitive status, except for an increase in the slow afterhyperpolarization in aged cholinergic neurons, independent of cognitive status. Furthermore, acutely dissociated basal forebrain neurons in which choline acetyltransferase mRNA was detected had the electrophysiological profiles of identified cholinergic neurons. We conclude that enhanced Ca(2+) buffering by cholinergic basal forebrain neurons may be important during aging.
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