ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Neuronal circuit remodeling in the contralateral cortical hemisphere during functional recovery from cerebral infarction.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 165 citations in OpenAlex.
- Targeted Neuromodulation of Abnormal Interhemispheric Connectivity to Promote Neural Plasticity and Recovery of Arm Function after Stroke: A Randomized Crossover Clinical Trial Study Protocol.Neural plasticity · 2018Trial
- Low-frequency rTMS in patients with subacute ischemic stroke: clinical evaluation of short and long-term outcomes and neurophysiological assessment of cortical excitability.Journal of medicine and lifeTrial
- Ischemic stroke triggers brain-wide synaptic remodeling within four hours.PLoS biology · 2026Article
- Nrg1 regulates cortical wiring and motor recovery upon traumatic injury.Frontiers in cellular neuroscience · 2026Article
- Neural repair mechanisms after ischemic stroke.Inflammation and regeneration · 2025Review
- Astrocytes in functional recovery following central nervous system injuries.The Journal of physiology · 2024Review
- Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity.Brain : a journal of neurology · 2024Article
- Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery.Neuroscience bulletin · 2022Review
- Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction.Neural regeneration research · 2022Article
- Astrocyte-secreted chordin-like 1 regulates spine density after ischemic injury.Scientific reports · 2022Article
- How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?Frontiers in systems neuroscience · 2022Review
- Rapid and Bihemispheric Reorganization of Neuronal Activity in Premotor Cortex after Brain Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Learning and Stroke Recovery: Parallelism of Biological Substrates.Seminars in neurology · 2021Review
- Evidence for a Window of Enhanced Plasticity in the Human Motor Cortex Following Ischemic Stroke.Neurorehabilitation and neural repair · 2021Article
- Sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke.Brain communications · 2020Article
- Translating concepts of neural repair after stroke: Structural and functional targets for recovery.Restorative neurology and neuroscience · 2020Review
- Role of Interhemispheric Cortical Interactions in Poststroke Motor Function.Neurorehabilitation and neural repair · 2019Article
- Post-stroke neuronal circuits and mental illnesses.International journal of physiology, pathophysiology and pharmacology · 2019Review
- Exercise training increases spatial memory via reducing contralateral hippocampal NMDAR subunits expression in intracerebral hemorrhage rats.Neuropsychiatric disease and treatment · 2019Article
- Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke.Neural plasticity · 2019Review
4 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in functional imaging of human brain activity in stroke patients, e.g., functional magnetic resonance imaging, have revealed that cortical hemisphere contralateral to the infarction plays an important role in the recovery process. However, underlying mechanisms occurring in contralateral hemisphere during functional recovery have not been elucidated. We experimentally induced a complete infarction of somatosensory cortex in right hemisphere of mice and examined the neuronal changes in contralateral (left) somatosensory cortex during recovery. Both basal and ipsilateral somatosensory stimuli-evoked neuronal activity in left (intact) hemisphere transiently increased 2 d after stroke, followed by an increase in the turnover rate of usually stable mushroom-type synaptic spines at 1 week, observed by using two-photon imaging in vivo. At 4 weeks after stroke, when functional recovery had occurred, a new pattern of electrical circuit activity in response to somatosensory stimuli was established in intact ipsilateral hemisphere. Thus, the left somatosensory cortex can compensate for the loss of the right somatosensory cortex by remodeling neuronal circuits and establishing new sensory processing. This finding could contribute to establish the effective clinical treatments targeted on the intact hemisphere for the recovery of impaired functions and to achieve better quality of life of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.