ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Spikes and membrane potential oscillations in hair cells generate periodic afferent activity in the frog sacculus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
- Electroreceptors with a different kind of buzz.The Journal of physiology · 2026Article
- Efferent control of hair cells mechanically coupled by artificial membranes.Scientific reports · 2025Article
- High-frequency electrical tuning and linear filter properties of Knollenorgan electroreceptors of mormyrid electric fish.The Journal of physiology · 2025Article
- Dual-Cell Patch-Clamp Recording Revealed a Mechanism for a Ribbon Synapse to Process Both Digital and Analog Inputs and Outputs.Frontiers in cellular neuroscience · 2021Article
- Article
- Models of utricular bouton afferents: role of afferent-hair cell connectivity in determining spike train regularity.Journal of neurophysiology · 2017Article
- Heat pulse excitability of vestibular hair cells and afferent neurons.Journal of neurophysiology · 2016Article
- Voltage-Mediated Control of Spontaneous Bundle Oscillations in Saccular Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Exocytosis in the frog amphibian papilla.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- Sensory coding in oscillatory electroreceptors of paddlefish.Chaos (Woodbury, N.Y.) · 2011Article
- Spontaneous voltage oscillations and response dynamics of a Hodgkin-Huxley type model of sensory hair cells.Journal of mathematical neuroscience · 2011Article
- Multiple-timescale dynamics underlying spontaneous oscillations of saccular hair bundles.Biophysical journal · 2011Article
- Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Imaging electrical resonance in hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Efferent control of the electrical and mechanical properties of hair cells in the bullfrog's sacculus.PloS one · 2010Article
- Ion channels set spike timing regularity of mammalian vestibular afferent neurons.Journal of neurophysiology · 2010Article
- Molecular anatomy of the hair cell's ribbon synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Spontaneous dynamics and response properties of a Hodgkin-Huxley-type neuron model driven by harmonic synaptic noise.The European physical journal. Special topics · 2010Article
- Spontaneous oscillations, signal amplification, and synchronization in a model of active hair bundle mechanics.Physical review. E, Statistical, nonlinear, and soft matter physics · 2010Article
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2 authors.
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Abstract
To look for membrane potential oscillations that may contribute to sensory coding or amplification in the ear, we made whole-cell and perforated-patch recordings from hair cells and postsynaptic afferent neurites in the explanted frog sacculus, with mechanoelectrical transduction (MET) blocked. Small depolarizing holding currents, which may serve to replace the in vivo resting MET current, evoked all-or-none calcium spikes (39-75 mV amplitude) in 37% of hair cells tested, and continuous membrane potential oscillations (14-28 mV; 15-130 Hz) in an additional 14% of cells. Spiking hair cells were on average taller and thinner than nonspiking hair cells, and had smaller outward currents through delayed rectifier channels (I(KV)) and noninactivating calcium-activated potassium channels (I(BK,steady)), and larger inward rectifier currents (I(K1)). Some spiking hair cells fired only a brief train at the onset of a current step, but others could sustain repetitive firing (3-70 Hz). Partial blockade of I(BK) changed the amplitude and frequency of oscillations and spikes, and converted some nonspiking cells into spiking cells. Oscillatory hair cells preferentially amplified sinusoidal stimuli at frequencies near their natural oscillation frequency. Postsynaptic recordings revealed regularly timed bursts of EPSPs in some afferent neurites. EPSP bursts were able to trigger afferent spikes, which may be initiated at the sodium channel cluster located adjacent to the afferent axon's most peripheral myelin segment. These results show that some frog saccular hair cells can generate spontaneous rhythmic activity that may drive periodic background activity in afferent axons.
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