ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
35 citing papers in PubMed, 100 citations in OpenAlex.
- Anatomical and molecular features of the amygdalohippocampal transition area and its role in social and emotional behavior processes.Neuroscience and biobehavioral reviews · 2022Review
- Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: a multitracer positron emission tomography study.Molecular psychiatry · 2021Article
- Nerve injury alters restraint-induced activation of the basolateral amygdala in male rats.Brain structure & function · 2021Article
- Repurposing Ketamine in Depression and Related Disorders: Can This Enigmatic Drug Achieve Success?Frontiers in neuroscience · 2021Review
- Trait Anxiety Mediated by Amygdala Serotonin Transporter in the Common Marmoset.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework.Progress in brain research · 2019Article
- Extending the neurocircuitry of behavioural inhibition: a role for the bed nucleus of the stria terminalis in risk for anxiety disorders.General psychiatry · 2019Review
- Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Functional Connectivity within the Primate Extended Amygdala Is Heritable and Associated with Early-Life Anxious Temperament.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology.Molecular psychiatry · 2017Article
- Dispositional negativity: An integrative psychological and neurobiological perspective.Psychological bulletin · 2016Review
- Overexpressing Corticotropin-Releasing Factor in the Primate Amygdala Increases Anxious Temperament and Alters Its Neural Circuit.Biological psychiatry · 2016Article
- Altered responsiveness of BNST and amygdala neurons in trauma-induced anxiety.Translational psychiatry · 2016Article
- Imaging Dopamine and Serotonin Systems on MPTP Monkeys: A Longitudinal PET Investigation of Compensatory Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Intergenerational neural mediators of early-life anxious temperament.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Extending the amygdala in theories of threat processing.Trends in neurosciences · 2015Review
- Serotonergic, brain volume and attentional correlates of trait anxiety in primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Corticotropin releasing hormone and imaging, rethinking the stress axis.Nuclear medicine and biology · 2015Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The serotonin transporter (5-HTT) plays a critical role in regulating serotonergic neurotransmission and is implicated in the pathophysiology of anxiety and affective disorders. Positron emission tomography scans using [(11)C]DASB [(11)C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile] to measure 5-HTT availability (an index of receptor density and binding) were performed in 34 rhesus monkeys in which the relationship between regional brain glucose metabolism and anxious temperament was previously established. 5-HTT availability in the amygdalohippocampal area and bed nucleus of the stria terminalis correlated positively with individual differences in a behavioral and neuroendocrine composite of anxious temperament. 5-HTT availability also correlated positively with stress-induced metabolic activity within these regions. Collectively, these findings suggest that serotonergic modulation of neuronal excitability in the neural circuitry associated with anxiety mediates the developmental risk for affect-related psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.