ArticleMolecular biology of the cell2009
The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Restorative macrophage-derived RNAseT2 stimulates muscle stem cell fusion via an SLK/N-WASP/actin bundling dependent axis.Nature communications · 2026Article
- The origin patterns, admixture, and selection signatures of the global gamecock populations.Poultry science · 2025Article
- LIM-domain binding protein 2 was down-regulated by miRNA-96-5p inhibited the proliferation, invasion and metastasis of lung cancer H1299 cells.Clinics (Sao Paulo, Brazil) · 2023Article
- Circuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase.Cell reports · 2022Article
- Hyaluronan Synthases' Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells.International journal of molecular sciences · 2021Article
- Ste20-like kinase, SLK, a novel mediator of podocyte integrity.American journal of physiology. Renal physiology · 2018Article
- Cytoglobin inhibits migration through PI3K/AKT/mTOR pathway in fibroblast cells.Molecular and cellular biochemistry · 2018Article
- Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.Skeletal muscle · 2017Article
- Regulation of Ste20-like kinase, SLK, activity: Dimerization and activation segment phosphorylation.PloS one · 2017Article
- Cofactors of LIM Domains Associate with Estrogen Receptor α to Regulate the Expression of Noncoding RNA H19 and Corneal Epithelial Progenitor Cell Function.The Journal of biological chemistry · 2016Article
- Regulation of Catalytic and Non-catalytic Functions of the Drosophila Ste20 Kinase Slik by Activation Segment Phosphorylation.The Journal of biological chemistry · 2015Article
- From hairballs to an understanding of transendothelial migration of monocytes in atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells.ASN neuro · 2014Article
- SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration.Oncogene · 2013Article
- Distinct roles for Ste20-like kinase SLK in muscle function and regeneration.Skeletal muscle · 2013Article
- Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.The Journal of cell biology · 2012Article
- Germinal center kinases in immune regulation.Cellular & molecular immunology · 2012Review
- FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.Science signaling · 2012Article
- Article
- Ste20-like kinase SLK, at the crossroads: a matter of life and death.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Cell migration involves a multitude of signals that converge on cytoskeletal reorganization, essential for development, immune responses, and tissue repair. Here, we show that the microtubule-associated Ste20 kinase SLK, required for cell migration, interacts with the LIM domain binding transcriptional cofactor proteins Ldb1/CLIM2 and Ldb2/CLIM1/NLI. We demonstrate that Ldb1 and 2 bind directly to the SLK carboxy-terminal AT1-46 homology domain in vitro and in vivo. We find that Ldb1 and -2 colocalize with SLK in migrating cells and that both knockdown and overexpression of either factor results in increased motility. Supporting this, knockdown of Ldb1 increases focal adhesion turnover and enhances migration in fibroblasts. We propose that Ldb1/2 function to maintain SLK in an inactive state before its activation. These findings highlight a novel function for Ldb1 and -2 and expand their role to include the control of cell migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.