ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 78 citations in OpenAlex.
- Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes.PLoS genetics · 2024Article
- Single-cell profiling of muscle-infiltrating T cells in idiopathic inflammatory myopathies.EMBO molecular medicine · 2023Article
- Trained Innate Immunity Not Always Amicable.International journal of molecular sciences · 2019Review
- CD4+CD28+KIR+CD11aJournal of autoimmunity · 2018Article
- Epigenetics in SLE.Current rheumatology reports · 2017Review
- DNA methylation in systemic lupus erythematosus.Epigenomics · 2017Review
- Analysis of killer cell immunoglobulin-like receptors (KIRs) and their HLA ligand genes polymorphisms in Iranian patients with systemic sclerosis.Clinical rheumatology · 2017Article
- DUSP23 is over-expressed and linked to the expression of DNMTs in CD4Clinical and experimental immunology · 2017Article
- DNA methylation alterations in the pathogenesis of lupus.Clinical and experimental immunology · 2017Review
- Protein Phosphatase 5 Contributes to the Overexpression of Epigenetically Regulated T-Lymphocyte Genes in Patients with Lupus.Lupus (Los Angeles) · 2016Article
- Epigenetics in systemic lupus erythematosus.Biomedical reports · 2016Article
- Characterisation of an epigenetically altered CD4(+) CD28(+) Kir(+) T cell subset in autoimmune rheumatic diseases by multiparameter flow cytometry.Lupus science & medicine · 2016Article
- CD4(+) T cells epigenetically modified by oxidative stress cause lupus-like autoimmunity in mice.Journal of autoimmunity · 2015Article
- Environmental factors, toxicants and systemic lupus erythematosus.International journal of molecular sciences · 2014Review
- Article
- Oxidative stress, T cell DNA methylation, and lupus.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Review
- Potential of epigenetic therapies in non-cancerous conditions.Frontiers in genetics · 2014Review
- Biomarkers in systemic lupus erythematosus: challenges and prospects for the future.Therapeutic advances in musculoskeletal disease · 2013Article
- Gene-function studies in systemic lupus erythematosus.Nature reviews. Rheumatology · 2013Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
T cells from lupus patients have hypomethylated DNA and overexpress genes normally suppressed by DNA methylation that contribute to disease pathogenesis. We found that stimulatory and inhibitory killer cell Ig-like receptor (KIR) genes are aberrantly overexpressed on experimentally demethylated T cells. We therefore asked if lupus T cells also overexpress KIR, and if the proteins are functional. T cells from lupus patients were found to overexpress KIR genes, and expression was proportional to disease activity. Abs to the stimulatory molecule KIR2DL4 triggered IFN-gamma release by lupus T cells, and production was proportional to disease activity. Similarly, cross-linking the inhibitory molecule KIR3DL1 prevented the autoreactive macrophage killing that characterizes lupus T cells. These results indicate that aberrant T cell KIR expression may contribute to IFN overproduction and macrophage killing in human lupus, and they suggest that Abs to inhibitory KIR may be a treatment for this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.