ArticlePlant physiology2009
Multiple antibiotic resistance in Arabidopsis is conferred by mutations in a chloroplast-localized transport protein.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 93 citations in OpenAlex.
- OsFPN1 functions as an essential metal transporter for Fe homeostasis and Co/Ni tolerance in rice.Plant molecular biology · 2026Article
- Professor Jeeyon Jeong (1977-2024), an insightful scholar and generous mentor.Frontiers in plant science · 2026Article
- Optimization of selection agent concentrations and expanding G418 utility for gentamicin resistance in Marchantia polymorpha.Scientific reports · 2025Article
- Research progress on the biosynthesis and delivery of iron-sulfur clusters in the plastid.Plant cell reports · 2023Review
- A dynamic compartment model for xylem loading and long-distance transport of iron explains the effect of kanamycin on metal uptake inFrontiers in plant science · 2023Article
- Iron uptake of etioplasts is independent from photosynthesis but applies the reduction-based strategy.Frontiers in plant science · 2023Article
- Golgi-Localized OsFPN1 is Involved in Co and Ni Transport and Their Detoxification in Rice.Rice (New York, N.Y.) · 2022Article
- Iron in leaves: chemical forms, signalling, and in-cell distribution.Journal of experimental botany · 2022Review
- Knockout of Tobacco Homologs ofInternational journal of molecular sciences · 2022Article
- Ferroportin 3 is a dual-targeted mitochondrial/chloroplast iron exporter necessary for iron homeostasis in Arabidopsis.The Plant journal : for cell and molecular biology · 2021Article
- Loss of MAR1 Function is a Marker for Co-Selection of CRISPR-Induced Mutations in Plants.Frontiers in genome editing · 2021Article
- Regulation of Iron Homeostasis and Use in Chloroplasts.International journal of molecular sciences · 2020Review
- Article
- A sense of place: transcriptomics identifies environmental signatures in Cabernet Sauvignon berry skins in the late stages of ripening.BMC plant biology · 2020Article
- Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum Stress.International journal of molecular sciences · 2020Article
- The Adaptive Mechanism of Plants to Iron Deficiency via Iron Uptake, Transport, and Homeostasis.International journal of molecular sciences · 2019Review
- Chloroplasts preferentially take up ferric-citrate over iron-nicotianamine complexes in Brassica napus.Planta · 2019Article
- Roles of Chloroplast Retrograde Signals and Ion Transport in Plant Drought Tolerance.International journal of molecular sciences · 2018Review
- Plastid translation is essential for lateral root stem cell patterning inBiology open · 2018Article
- Chloroplast Iron Transport Proteins - Function and Impact on Plant Physiology.Frontiers in plant science · 2016Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Widespread antibiotic resistance is a major public health concern, and plants represent an emerging antibiotic exposure route. Recent studies indicate that crop plants fertilized with antibiotic-laden animal manure accumulate antibiotics; however, the molecular mechanisms of antibiotic entry and subcellular partitioning within plant cells remain unknown. Here, we report that mutations in the Arabidopsis (Arabidopsis thaliana) locus Multiple Antibiotic Resistance1 (MAR1) confer resistance, while MAR1 overexpression causes hypersensitivity to multiple aminoglycoside antibiotics. Additionally, yeast expressing MAR1 are hypersensitive to the aminoglycoside G418. MAR1 encodes a protein with 11 putative transmembrane domains with low similarity to ferroportin1 from Danio rerio. A MAR1:yellow fluorescent protein fusion localizes to the chloroplast, and chloroplasts from plants overexpressing MAR1 accumulate more of the aminoglycoside gentamicin, while mar1-1 mutant chloroplasts accumulate less than the wild type. MAR1 overexpression lines are slightly chlorotic, and chlorosis is rescued by exogenous iron. MAR1 expression is also down-regulated by low iron. These data suggest that MAR1 is a plastid transporter that is likely to be involved in cellular iron homeostasis and allows opportunistic entry of multiple antibiotics into the chloroplast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.