ArticleDevelopment (Cambridge, England)2009
Systematic analysis of dynamic miRNA-target interactions during C. elegans development.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- Xeroderma pigmentosum protein XPD controls caspase-mediated stress responses.Nature communications · 2024Article
- Characterization of the regulation mechanism of grapevine microRNA172 family members during flower development.BMC plant biology · 2020Article
- Sweet Control: MicroRNA Regulation of the Glycome.Biochemistry · 2020Review
- Down-regulated miR-495 can target programmed cell death 10 in ankylosing spondylitis.Molecular medicine (Cambridge, Mass.) · 2020Article
- Recent Molecular Genetic Explorations ofGenetics · 2018Article
- Article
- MicroRNAs of Toxocara canis and their predicted functional roles.Parasites & vectors · 2016Article
- Functional relevance of "seed" and "non-seed" sequences in microRNA-mediated promotion of C. elegans developmental progression.RNA (New York, N.Y.) · 2015Article
- Short interspersed DNA elements and miRNAs: a novel hidden gene regulation layer in zebrafish?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- The BDNF Val66Met variant affects gene expression through miR-146b.Neurobiology of disease · 2015Article
- Article
- microRNAs of parasitic helminths - Identification, characterization and potential as drug targets.International journal for parasitology. Drugs and drug resistance · 2014Review
- Insights into miRNA regulation of the human glycome.Biochemical and biophysical research communications · 2014Article
- Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- MicroRNA binding sites in C. elegans 3' UTRs.RNA biology · 2014Article
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- Article
- Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a.Journal of biomedical science · 2013Article
- Tertiary structure-based analysis of microRNA-target interactions.RNA (New York, N.Y.) · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Although microRNA (miRNA)-mediated functions have been implicated in many aspects of animal development, the majority of miRNA::mRNA regulatory interactions remain to be characterized experimentally. We used an AIN/GW182 protein immunoprecipitation approach to systematically analyze miRNA::mRNA interactions during C. elegans development. We characterized the composition of miRNAs in functional miRNA-induced silencing complexes (miRISCs) at each developmental stage and identified three sets of miRNAs with distinct stage-specificity of function. We then identified thousands of miRNA targets in each developmental stage, including a significant portion that is subject to differential miRNA regulation during development. By identifying thousands of miRNA family-mRNA pairs with temporally correlated patterns of AIN-2 association, we gained valuable information on the principles of physiological miRNA::target recognition and predicted 1589 high-confidence miRNA family::mRNA interactions. Our data support the idea that miRNAs preferentially target genes involved in signaling processes and avoid genes with housekeeping functions, and that miRNAs orchestrate temporal developmental programs by coordinately targeting or avoiding genes involved in particular biological functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.