ArticleThe Journal of physiology2009
High temperature does not alter fatigability in intact mouse skeletal muscle fibres.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- The Impact of Fucoidan Extracts on Heat-Stress-Induced Loss of In Vitro Fast-Twitch Muscle Function in Mice.Muscles (Basel, Switzerland) · 2025Article
- The temperature sensitivity of motor units in rat soleus.Scientific reports · 2024Article
- CaScientific reports · 2024Article
- Endogenous and Exogenous Antioxidants in Skeletal Muscle Fatigue Development during Exercise.Antioxidants (Basel, Switzerland) · 2023Review
- Modulation of neuromuscular excitability in response to acute noxious heat exposure has no additional effects on central and peripheral fatigability.Frontiers in physiology · 2022Article
- The likely effects of thermal climate change on vertebrate skeletal muscle mechanics with possible consequences for animal movement and behaviour.Conservation physiology · 2019Review
- Sports and environmental temperature: From warming-up to heating-up.Temperature (Austin, Tex.) · 2017Review
- Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery.The Journal of physiology · 2016Review
- Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres.The Journal of physiology · 2015Article
- Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species.Frontiers in physiology · 2015Review
- Humanized animal exercise model for clinical implication.Pflugers Archiv : European journal of physiology · 2014Review
- The excitation-contraction coupling mechanism in skeletal muscle.Biophysical reviews · 2014Review
- Hot ambient conditions shift the Force / EMG relationship.SpringerPlus · 2013Article
- Doublet discharge stimulation increases sarcoplasmic reticulum Ca2+ release and improves performance during fatiguing contractions in mouse muscle fibres.The Journal of physiology · 2013Article
- A review of the thermal sensitivity of the mechanics of vertebrate skeletal muscle.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2013Review
- Effect of temperature on crossbridge force changes during fatigue and recovery in intact mouse muscle fibers.PloS one · 2013Article
- ROS-mediated decline in maximum Ca2+-activated force in rat skeletal muscle fibers following in vitro and in vivo stimulation.PloS one · 2012Article
- Antioxidants and Skeletal Muscle Performance: "Common Knowledge" vs. Experimental Evidence.Frontiers in physiology · 2012Article
- Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle.The Journal of physiology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intense activation of skeletal muscle results in fatigue development, which involves impaired function of the muscle cells resulting in weaker and slower contractions. Intense muscle activity also results in increased heat production and muscle temperature may rise by up to 6 degrees C. Hyperthermia is associated with impaired exercise performance in vivo and recent studies have shown contractile dysfunction and premature fatigue development in easily fatigued muscle fibres stimulated at high temperatures and these defects were attributed to oxidative stress. Here we studied whether fatigue-resistant soleus fibres stimulated at increased temperature show premature fatigue development and whether increasing the level of oxidative stress accelerates fatigue development. Intact single fibres or small bundles of soleus fibres were fatigued by 600 ms tetani given at 2 s intervals at 37 degrees C and 43 degrees C, which is the highest temperature the muscle would experience in vivo. Tetanic force in the unfatigued state was not significantly different at the two temperatures. With 100 fatiguing tetani, force decreased by approximately 15% at both temperatures; the free cytosolic [Ca(2+)] (assessed with indo-1) showed a similar approximately 10% decrease at both temperatures. The oxidative stress during fatigue at 43 degrees C was increased by application of 10 microM hydrogen peroxide or tert-butyl hydroperoxide and this did not cause premature fatigue development. In summary, fatigue-resistant muscle fibres do not display impaired contractility and fatigue resistance at the highest temperature that mammals, including humans, would experience in vivo. Thus, intrinsic defects in fatigue-resistant muscle fibres cannot explain the decreased physical performance at high temperatures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.