ArticleBMC neurology2009
Fluorodeoxyglucose-positron emission tomography in the differential diagnosis of early-onset dementia: a prospective, community-based study.
Article in BMC neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Diagnostic Performance of Generative Adversarial Network-Based Deep Learning Methods for Alzheimer's Disease: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2022Pooled it
- Accuracy of FDG-PET brain scan to differentiate sporadic bvFTD of mild severity from late onset psychiatric disorders.Journal of neurology · 2025Article
- Cutting-edge Strategies for Overcoming Therapeutic Barriers in Alzheimer's Disease.Current pharmaceutical design · 2025Review
- Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorder.International journal of bipolar disorders · 2024Article
- The Usefulness ofDementia and neurocognitive disorders · 2024Article
- The use of neuroimaging techniques in the early and differential diagnosis of dementia.Molecular psychiatry · 2023Review
- Neuroimaging of Mouse Models of Alzheimer's Disease.Biomedicines · 2022Review
- Anomaly detection for the individual analysis of brain PET images.Journal of medical imaging (Bellingham, Wash.) · 2021Article
- Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring.International journal of molecular sciences · 2021Review
- The Clinical Spectrum of Young Onset Dementia Points to Its Stochastic Origins.Journal of Alzheimer's disease reports · 2021Article
- Comparison of the clinical impact of 2-[18F]FDG-PET and cerebrospinal fluid biomarkers in patients suspected of Alzheimer's disease.PloS one · 2021Article
- Ophthalmic Biomarkers for Alzheimer's Disease: A Review.Frontiers in aging neuroscience · 2021Review
- Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders.Brain : a journal of neurology · 2020Review
- Clinical utility of FDG-PET for the differential diagnosis among the main forms of dementia.European journal of nuclear medicine and molecular imaging · 2018Review
- Usefulness of 3-dimensional stereotactic surface projection FDG PET images for the diagnosis of dementia.Medicine · 2016Article
- Cerebral perfusion and glucose metabolism in Alzheimer's disease and frontotemporal dementia: two sides of the same coin?European radiology · 2015Article
- FDG-PET Contributions to the Pathophysiology of Memory Impairment.Neuropsychology review · 2015Review
- Brain Metabolism of Less-Educated Patients With Alzheimer Dementia Studied by Positron Emission Tomography.Medicine · 2015Article
- Imaging biomarkers associated with cognitive decline: a review.Biological psychiatry · 2015Review
- Multimodality imaging of Alzheimer disease and other neurodegenerative dementias.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the diagnostic accuracy of positron emission tomography (PET) using F18 fluorodeoxyglucose (FDG) in the differential diagnosis of early-onset Alzheimer's disease (AD) and other dementias in a community-dwelling population.
methodsA prospective sample of 102 individuals presenting consecutively to a primary care centre for examination of suspected early-onset dementing diseases. The mean age of symptom onset of dementia in our patients was 60.06 +/- 4.28 years (mean +/- 1 SD, 95% lower confidence intervals (CI) 54.75, upper 63.37). Patients were evaluated using standard clinical criteria for the diagnosis of dementia. Functional neuroimaging data was obtained and nuclear medicine physicians blind to the clinical diagnosis generated FDG-PET diagnoses. Final clinical diagnoses based on all available data were then established and compared against PET diagnoses.
resultsForty-nine patients received a final clinical diagnosis of early-stage AD (MMSE score 20.97 +/- 5.10). There were 29 non-AD demented patients, 11 depressed patients and a miscellaneous group of 13 patients. Among patients with AD, the sensitivity and specificity of FDG-PET was 78% (95% CI: 66-90%) and 81% (95% CI: 68-86%), respectively. The positive likelihood ratio (PLR) for a FDG-PET scan positive for the diagnosis of AD was 4.11 (95% CI: 2.29-7.32) and negative likelihood ratio (NLR) for a negative FDG-PET scan in the absence of AD was 0.27 (95% CI: 0.16-0.46). The pre-test probability was 48% and post-test probability was 79.02%. The specificity of FDG-PET in the differential diagnosis of other dementias, including frontotemporal dementia, was greater than 95%. Recruitment methods in this study provide a sample that may be more representative of patients in the general population and indicate that FDG-PET imaging can contribute to the diagnosis of AD in younger adults with major increases in the positive likelihood rates and post-test probability.
conclusionThe high specificity of FDG-PET suggests this technique might help in the diagnosis of frontotemporal dementia and other forms of early-onset dementia.
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