ReviewNutrition reviews2009
Mendelian randomization in nutritional epidemiology.
Review in Nutrition reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study.BMC cancer · 2020Pooled it
- Coffee consumption and liver cancer risk in Japan: a meta-analysis of six prospective cohort studies.Nagoya journal of medical science · 2019Pooled it
- Macronutrient-specific effect of theJournal of lipid research · 2018Trial
- Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial.The Journal of nutrition · 2015Trial
- Variants in glucose- and circadian rhythm-related genes affect the response of energy expenditure to weight-loss diets: the POUNDS LOST Trial.The American journal of clinical nutrition · 2014Trial
- The association between diet and bladder cancer risk: a two-sample mendelian randomization.European journal of nutrition · 2025Article
- Ultra-Processed Food and Its Impact on Bone Health and Joint Diseases: A Scoping Review.Nutrients · 2025Article
- Mendelian randomization study of serum uric acid levels and urate-lowering drugs on pulmonary arterial hypertension outcomes.Scientific reports · 2025Article
- Associations between Sjogren syndrome and psychiatric disorders in European populations: a 2-sample bidirectional Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Article
- Article
- Editorial: Causal inference in diet, nutrition and health outcomes.Frontiers in nutrition · 2023Article
- Prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches.European journal of epidemiology · 2022Article
- Article
- Bidirectional Mendelian Randomization Analysis for Vitamin D and Thyroid Peroxidase Antibody.International journal of endocrinology · 2022Article
- Genetic and Genomic Advances in Developmental Models: Applications for Nutrition Research.Advances in nutrition (Bethesda, Md.) · 2020Review
- Evidence of a Causal Association Between Cancer and Alzheimer's Disease: a Mendelian Randomization Analysis.Scientific reports · 2019Article
- DNA methylation variant, B-vitamins intake and longitudinal change in body mass index.International journal of obesity (2005) · 2019Article
- The Circadian Rhythm-Related MTNR1B Genotype, Gestational Weight Gain, and Postpartum Glycemic Changes.The Journal of clinical endocrinology and metabolism · 2018Article
- Use of MendelianFrontiers in genetics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Nutritional epidemiology aims to identify dietary and lifestyle causes for human diseases. Causality inference in nutritional epidemiology is largely based on evidence from studies of observational design, and may be distorted by unmeasured or residual confounding and reverse causation. Mendelian randomization is a recently developed methodology that combines genetic and classical epidemiological analysis to infer causality for environmental exposures, based on the principle of Mendel's law of independent assortment. Mendelian randomization uses genetic variants as proxies for environmental exposures of interest. Associations derived from Mendelian randomization analysis are less likely to be affected by confounding and reverse causation. During the past 5 years, a body of studies examined the causal effects of diet/lifestyle factors and biomarkers on a variety of diseases. The Mendelian randomization approach also holds considerable promise in the study of intrauterine influences on offspring health outcomes. However, the application of Mendelian randomization in nutritional epidemiology has some limitations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.