ArticleBiochemistry2009
Occidiofungin, a unique antifungal glycopeptide produced by a strain of Burkholderia contaminans.
Article in Biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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Who cites it
54 citing papers in PubMed, 113 citations in OpenAlex.
- Antifungal activity of Burkholderia sensu lato metabolites against coffee phytopathogens: evidence of chemical diversity.World journal of microbiology & biotechnology · 2026Article
- Genomic Basis of Lifestyle Divergence in Rice-AssociatedInternational journal of molecular sciences · 2026Article
- Biological control ofFrontiers in microbiology · 2026Article
- Ecological Diversity, Metabolic Versatility, and Biotechnological Applications ofAntibiotics (Basel, Switzerland) · 2025Review
- Recent advances in microbially derived chlorinated antiparasitic compounds.Molecular diversity · 2025Review
- Please inhibit responsibly: Natural and synthetic actin toxins as useful tools in cell biology.Molecular biology of the cell · 2025Review
- Isolation and Identification ofMicroorganisms · 2025Article
- Article
- Development of an LC-MS/MS Method for Quantifying Occidiofungin in Rabbit Plasma.Journal of mass spectrometry : JMS · 2025Article
- Quorum sensing and DNA methylation play active roles in clinicalJournal of bacteriology · 2025Article
- Invasibility of a North American soil ecosystem to amphibian-killing fungal pathogens.Proceedings. Biological sciences · 2024Article
- Previously Uncharacterized Variants, OCF-E-OCF-J, of the Antifungal Occidiofungin Produced byJournal of natural products · 2024Article
- Natural and engineered xylosyl products from microbial source.Natural products and bioprospecting · 2024Review
- Comparative Genome Analyses Provide Insight into the Antimicrobial Activity of EndophyticMicroorganisms · 2024Article
- Intravaginal Gel for Sustained Delivery of Occidiofungin and Long-Lasting Antifungal Effects.Gels (Basel, Switzerland) · 2023Article
- Microbial Metabolites Beneficial to Plant Hosts Across Ecosystems.Microbial ecology · 2023Review
- Compilation of the Antimicrobial Compounds Produced byMolecules (Basel, Switzerland) · 2023Review
- Genomic Analysis of the Rare Slightly Halophilic Myxobacterium "Microorganisms · 2023Article
- Potential Biocontrol Activities ofPathogens (Basel, Switzerland) · 2022Article
- Structure and Biosynthesis of Desmamides A-C, Lipoglycopeptides from the Endophytic CyanobacteriumJournal of natural products · 2022Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Bacterial strain Burkholderia contaminans MS14 was isolated from soil that suppressed brown patch disease of lawn grass. An antifungal compound was purified from the liquid culture of this bacterium. In this study, complete covalent structures of two purified closely related antifungal compounds were determined by the experiments of TOCSY, NOESY, ROESY, 13C HSQC 2D NMR, and ESI-MS and GC. The analysis of monoisotopic masses of the purified preparation indicated the presence of two related compounds with masses determined to be 1199.543 and 1215.518 Da; the difference corresponds to the mass of an oxygen atom. GC analysis identified a xylose sugar attached to the antifungal compound. NMR experiments revealed that the compound is cyclic and composed of eight amino acids, two of which are beta-hydroxy derivatives of Tyr and Asn, and one being a novel amino acid. The novel amino acid serves as the scaffold for the attachment of the xylose and a short acyl chain. The spectrum and concentration of antifungal activity were determined using a microtiter plate assay. The antifungal compound demonstrated potent antifungal activities against a broad panel of fungal plant and animal pathogens, as well as two Pythium spp. Microscopic observations showed that the antifungal compound disrupts normal membrane morphology. The cells fill with large inclusion bodies and the membrane becomes irregularly shaped and swollen following the exposure to subinhibitory concentrations of the antifungal compound. Our data support the identification of a novel fungicide and the compound has been named occidiofungin, meaning fungal killer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.